Key takeaways
Clomid (clomiphene) and Tamoxifen (Nolvadex) are both selective estrogen receptor modulators (SERMs), but they have some important differences. Clomid is primarily used to treat female infertility by inducing ovulation, while tamoxifen is used to treat and prevent hormone receptor-positive (HR+) breast cancer. Clomid is taken orally for 5 days during the menstrual cycle, whereas tamoxifen is typically taken once daily for several years, depending on the condition being treated. Both medications are available as a lower-cost generic. Common side effects of Clomid include hot flashes and stomach pain. Tamoxifen can cause hot flashes, vaginal discharge, and swelling in the arms and legs. While Clomid is not recommended for long-term use, tamoxifen is often used long-term but can increase the risk for serious side effects such as blood clots and uterine cancer. Both medications should be avoided during pregnancy due to potential harm to an unborn baby.
