Key takeaways
Sulindac and naproxen (Naprosyn) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation. But they have several differences. Sulindac is typically prescribed for various types of arthritis and certain shoulder injuries, while naproxen is used for a broader range of conditions, including arthritis, gout, and tendonitis. Sulindac is usually taken twice daily, whereas naproxen can be taken 2 to 3 times per day, depending on the condition being treated. But both medications should be taken with food to prevent an upset stomach. Sulindac and naproxen can cause serious side effects like stomach bleeding, heart attack, and stroke. Naproxen comes as a liquid form option for those who have trouble swallowing pills. Additionally, naproxen is available over-the-counter in a lower strength (Aleve), while sulindac is only available by prescription. Both medications should be taken with caution, especially if you have heart, liver, or kidney problems.
