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Climara Pro vs. Climara

Climara Pro is a patch that's applied to the skin once a week. It's approved to prevent osteoporosis in people who've gone through menopause. This medication can also treat symptoms like hot flashes and night sweats from menopause. The patch is a hormone replacement therapy; it contains the hormones estradiol and levonorgestrel. Side effects include irregular vaginal bleeding or spotting, breast pain, and skin irritation where the patch is applied.

• Treatment of moderate-to-severe symptoms of menopause (e.g., hot flashes, night sweats) for people with a healthy uterus
• Prevention of osteoporosis for people who've gone through menopause with a healthy uterus

• Application site reaction (e.g., skin irritation; 41%)
• Vaginal bleeding or spotting (37%)
• Breast pain (19%)
• Upper respiratory infection (13%)
• Depression (6%)
• Back pain (6%)
• General pain (5%)
• Headache (5%)
• Flu-like symptoms (5%)

• Blood clots and related complications (e.g., heart attacks, strokes)
• Breast cancer
• Uterine or endometrial cancer
• Ovarian cancer
• Risk for dementia
• Gallbladder problems and jaundice
• Changes in calcium levels in the blood
• Changes in vision
• High triglyceride (fat) levels
• Low thyroid hormone levels in people who take thyroid hormone replacement therapy
• Buildup of fluids in your body (fluid retention)

The Climara (estradiol patch) is a once-weekly hormonal patch that relieves menopause symptoms and treats low estrogen levels. It can also help prevent bone loss (osteoporosis) in people who have gone through menopause. The patch is a type of hormone replacement therapy (HRT) and typically has fewer side effects than oral estrogen pills. You'll apply one patch to the skin of your lower stomach or the upper buttocks once a week. Potential side effects of this hormone patch include breast pain, headaches, and stomach pain.

• Hot flashes, night sweats, and flushes caused by menopause
• Vaginal dryness and irritation caused by menopause
• Low estrogen levels due to certain conditions
• Prevention of osteoporosis after menopause

• Breast pain (up to 29%)
• Headache (up to 18%)
• Upper respiratory tract infection (up to 17%)
• Stomach pain (up to 16%)
• Swelling (up to 13%)
• Back and body pain (up to 11%)
• Depression (up to 8%)
• Vaginal discharge (up to 7%)
• Excessive gas (up to 7%)
• Itching (up to 6%)
• Nausea (up to 6%)

• Blood clots and related complications (e.g., heart attack, stroke)
• Uterine (endometrial) cancer
• Breast cancer
• Ovarian cancer
• Dementia
• Gallbladder and liver problems
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Worsening of other health conditions