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Breo Ellipta vs. Trelegy Ellipta

Breo Ellipta (fluticasone furoate / vilanterol) is a maintenance inhaler used every day to help manage asthma and chronic obstructive pulmonary disease (COPD). It's a combination of two medications: fluticasone, a corticosteroid that reduces swelling in your lungs, and vilanterol, a long-acting beta agonist (LABA) that helps relax your airways. The typical dose is one puff by mouth once a day. Breo Ellipta (fluticasone furoate / vilanterol) isn't for sudden breathing problems or asthma attacks. Side effects include oral thrush, sore throat, and headache.

• Asthma - in adults and children 5 years and older
• Chronic obstructive pulmonary disease (COPD) - in adults

Asthma (adults):

• Common cold symptoms (7-10%)
• Headache (5-8%)

Asthma (children):

• Common cold symptoms (10%)
• Upper respiratory tract infection (7%)

COPD:

• Common cold symptoms (9%)
• Upper respiratory tract infection (7%)
• Headache (7%)
• Oral thrush (5%)

• Worsening asthma or COPD
• Overdose
• Oral thrush
• Pneumonia
• Higher risk of infection
• Changes in stress hormone levels
• Sudden narrowing of the airways
• Serious allergic reactions
• Heart problems
• Risk of bone loss
• Slowed growth in children
• Eye problems
• High blood sugar and low potassium

Trelegy Ellipta is a combination maintenance inhaler used to treat adults with chronic obstructive pulmonary disease (COPD) and asthma. It contains three active ingredients: fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). Together, these help reduce airway inflammation, relax airway muscles, and help keep your airways open. The typical dose is one puff inhaled through the mouth once a day. Common side effects include headache, cough, and back pain.

• Maintenance treatment of asthma
• Maintenance treatment of chronic obstructive pulmonary disease (COPD)

COPD:

• Headache (4%)
• Back pain (4%)
• Changes in taste (2%)
• Diarrhea (2%)

Asthma:

• Common cold symptoms (up to 17%)
• Headache (up to 9%)
• Upper respiratory tract infection (up to 7%)
• Bronchitis (up to 5%)
• Sinus infection (up to 3%)
• Back pain (up to 3%)

• Worsening symptoms or sudden flare-ups
• Overdose
• Oral thrush
• Pneumonia
• Risk of infection
• Changes in stress hormone levels
• Sudden narrowing of the airways
• Serious allergic reaction
• Heart problems
• Weaker bones
• Eye problems
• Trouble urinating
• Worsening of certain health conditions
• Low potassium and high blood sugar