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Atrovent HFA vs. Combivent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Atrovent HFA (ipratropium) and Combivent Respimat (ipratropium/albuterol) are both used to help with breathing issues, but they have different uses and forms. Atrovent HFA is an inhaled anticholiergic medication used as maintenance treatment for chronic obstructive pulmonary disease (COPD). It works by blocking acetylcholine in the lungs, which allows the muscles in your airway to relax, making it easier to breathe. Combivent Respimat, on the other hand, is an inhaler used to treat chronic obstructive pulmonary disease (COPD) and contains a combination of ipratropium and albuterol. This means combines the effects of a short-acting muscarinic antagonist (SAMA) and a short-acting beta-agonist (SABA) to relax and open airways. Both medications are brand-name only. Atrovent HFA is typically used four times a day, whereas Combivent Respimat is used up to 6 times a day for breathing issues.

Atrovent HFA

(ipratropium)

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Combivent Respimat

(ipratropium / albuterol)

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Summary for Atrovent HFA

Prescription only

Atrovent HFA (ipratropium) is a short-acting inhaled anticholinergic medication used to help with difficulty breathing in people with chronic obstructive pulmonary disease (COPD). This medication comes in an inhaler. Typically, you breathe in 2 inhalations, 4 times a day. You should use Atrovent HFA (ipratropium) regularly every day in order it for it to keep your COPD symptoms under control. It's not meant to be used as a rescue inhaler.

Indications for Atrovent HFA

Pros and Cons for Atrovent HFA

Pros

  • Works well as a maintenance treatment for COPD
  • Small inhaler, so easy to take with you, compared to the nebulized ipratropium
  • Not many interactions with other medications

Cons

  • Need to use 2 puffs (inhalations) every 4 hours
  • Not a rescue inhaler
  • It's not completely clear how safe it is for pregnant or breastfeeding females

Common Side Effects for Atrovent HFA

  • Cough and other symptoms of bronchitis (10-23%)
  • Worsened COPD symptoms (8-23%)
  • Trouble breathing (7-8%)
  • Tiredness, chills, and other flu-like symptoms (4-8%)
  • Headache (6-7%)
  • Back pain (2-7%)

Warnings for Atrovent HFA

  • Severe allergic reactions
  • Narrowing of your airways (bronchospasm)
  • Risk of eye and vision problems
  • Trouble urinating

Summary for Combivent

Prescription only

Combivent Respimat is an inhaler that's used to treat chronic obstructive pulmonary disease (COPD) in adults. It's a combination medication that contains two different bronchodilators: ipratropium, a short-acting muscarinic antagonist (SAMA), and albuterol, a short-acting beta agonist (SABA). The medication is inhaled through the mouth 4 times a day, but up to 6 times per day if instructed. Combivent Respimat (ipratropium / albuterol) isn't a rescue inhaler; it's used regularly rather than as needed for sudden breathing problems. Side effects aren't common but can include upper respiratory tract infections and cough.

Indications for Combivent

Pros and Cons for Combivent

Pros

  • Combines two different bronchodilators within a single inhaler for convenience
  • Can start to work in about 15 minutes to help with breathing for some people
  • Doesn't require shaking before use
  • Don't need to rinse your mouth after use

Cons

  • Not a rescue inhaler
  • Might need to use up to 6 times per day, depending on the severity of your COPD symptoms
  • Might not be a good option for people with heart problems
  • No lower-cost generic; only available as a brand-name medication

Common Side Effects for Combivent

Warnings for Combivent

  • Narrowing of the airways (bronchospasm)
  • Effects on the heart and blood pressure
  • Eye problems
  • Trouble urinating
  • Severe allergic reaction
  • Low potassium in the blood

Prices with our coupons for Atrovent HFA vs. Combivent

Price Card Drug Icon
Ipratropium25 vials / 2.5ml of 0.02%
$14.40$71.36
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Combivent1 respimat inhaler / 120 doses of 20mcg/100mcg
$503.40$648.88
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