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Atrovent HFA vs. Advair

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ipratropium (Atrovent HFA) and fluticasone/salmeterol (Advair) are both prescription medications, but they serve different purposes and belong to different drug classes. Atrovent HFA is an inhaled anticholiergic medication used as maintenance treatment for chronic obstructive pulmonary disease (COPD). It works by blocking acetylcholine in the lungs, which allows the muscles in your airway to relax, making it easier to breathe. Advair is an inhaler that combines fluticasone, an inhaled corticosteroid, and salmeterol, a long-acting beta agonist (LABA). Advair is used for the maintenance treatment of asthma and COPD by reducing inflammation and relaxing lung muscles. Atrovent HFA is only available as a brand name medication, while Advair is available in both brand and generic forms. Atrovent HFA is typically used four times a day, whereas Advair is used twice daily. Common side effects of Atrovent HFA include cough and headache, while Advair can cause upper respiratory infections and sore throat. Additionally, Advair requires rinsing your mouth after use to prevent fungal infections, a step not needed with Atrovent HFA.

Atrovent HFA

(ipratropium)

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Advair

(fluticasone / salmeterol)

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Summary for Atrovent HFA

Prescription only

Atrovent HFA (ipratropium) is a short-acting inhaled anticholinergic medication used to help with difficulty breathing in people with chronic obstructive pulmonary disease (COPD). This medication comes in an inhaler. Typically, you breathe in 2 inhalations, 4 times a day. You should use Atrovent HFA (ipratropium) regularly every day in order it for it to keep your COPD symptoms under control. It's not meant to be used as a rescue inhaler.

Indications for Atrovent HFA

Pros and Cons for Atrovent HFA

Pros

  • Works well as a maintenance treatment for COPD
  • Small inhaler, so easy to take with you, compared to the nebulized ipratropium
  • Not many interactions with other medications

Cons

  • Need to use 2 puffs (inhalations) every 4 hours
  • Not a rescue inhaler
  • It's not completely clear how safe it is for pregnant or breastfeeding females

Common Side Effects for Atrovent HFA

  • Cough and other symptoms of bronchitis (10-23%)
  • Worsened COPD symptoms (8-23%)
  • Trouble breathing (7-8%)
  • Tiredness, chills, and other flu-like symptoms (4-8%)
  • Headache (6-7%)
  • Back pain (2-7%)

Warnings for Atrovent HFA

  • Severe allergic reactions
  • Narrowing of your airways (bronchospasm)
  • Risk of eye and vision problems
  • Trouble urinating

Summary for Advair

Prescription only

Advair is a combination inhaler that contains fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting beta agonist, or LABA). Advair Diskus is used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults and children, where as Advair HFA is for asthma only. Advair (fluticasone / salmeterol) is inhaled through the mouth, typically 1 to 2 puffs twice daily. Some common side effects of this medication include upper respiratory tract infection, sore throat, and headache.

Indications for Advair

  • Maintenance treatment of asthma
  • Maintenance treatment of COPD - Advair Diskus 250/50 only

Pros and Cons for Advair

Pros

  • Works well to lower the risk of asthma or COPD symptoms
  • Combines two medications into a single inhaler for convenience
  • Available as two different types of inhalers (Advair Diskus and Advair HFA)

Cons

  • Can cause fungal infections (thrush) in your mouth and throat
  • Advair Diskus contains lactose, so it might not be safe for people with severe milk protein allergies
  • Doesn't replace your rescue inhaler

Common Side Effects for Advair

Advair Diskus:

  • Upper respiratory infection (up to 27%)
  • Sore throat (up to 13%)
  • Headache (up to 13%)
  • Bronchitis (up to 8%)
  • Cough (up to 6%)
  • Nausea and vomiting (up to 6%)
  • Hoarseness (up to 5%)

Advair HFA:

  • Upper respiratory infection (up to 24%)
  • Headache (up to 21%)
  • Throat irritation (up to 9%)
  • Muscle and bone pain (up to 7%)
  • Nausea and vomiting (up to 5%)

Warnings for Advair

  • Not for use in asthma attack or for worsening breathing
  • Fungal infection in the mouth
  • Narrowing of your airways (bronchospasm)
  • Higher risk of infections
  • Altered stress hormone levels
  • Delayed growth in children
  • Eye and vision problems
  • Heart problems
  • Low potassium levels in the blood
  • Allergic reactions

Prices with our coupons for Atrovent HFA vs. Advair

Price Card Drug Icon
Ipratropium25 vials / 2.5ml of 0.02%
$14.27$15.11
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Fluticasone/Salmeterol1 diskus inhaler / 250mcg/50mcg
$65.46$314.99
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