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Arazlo vs. Tretinoin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Arazlo (tazarotene) and Retin-A (tretinoin) are both topical retinoid medications used to treat acne. They work by promoting the growth of new skin cells and reducing oil and inflammation. Arazlo is approved for use in people as young as 9 years old, while Retin-A is approved for those ages 12 and older. Arazlo is available as a lotion with a concentration of 0.045%, whereas Retin-A comes in cream or gel form. Both medications are applied once daily, but Arazlo is typically used during the day, and Retin-A is applied at bedtime. Common side effects for both include skin irritation and increased sensitivity to sunlight, but Retin-A may also cause your skin color to temporarily change. Retin-A is available in a lower-cost generic form, while Arazlo is only available as a brand-name medication.

Arazlo

(tazarotene)

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Retin-A

(tretinoin)

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Summary for Arazlo

Prescription only

Arazlo, the brand name for tazarotene 0.045% lotion, is a retinoid that's approved for treating acne. It can be prescribed for people ages 9 years and older. This medication is applied directly to the affected areas of skin once per day. Side effects include dry skin and skin pain (such as burning or stinging). It also can raise your risk for sunburns. Even though Arazlo (tazarotene) is applied directly to the skin, it's not safe to use while pregnant.

Indications for Arazlo

Pros and Cons for Arazlo

Pros

  • A first-choice option for treating acne
  • Only applied once a day
  • Approved for children as young as 9 years old

Cons

  • Can make you sunburn more easily
  • Available by prescription only
  • Not safe to use while pregnant

Common Side Effects for Arazlo

  • Stinging, burning, or pain on the skin (5%)
  • Dry skin (4%)

Warnings for Arazlo

  • Harm to unborn baby
  • Skin irritation
  • Risk for sunburn

Summary for Tretinoin

Prescription only

Retin-A (tretinoin) is a retinoid medication that's used to treat acne in adults and children 12 years and older. It's available as a cream or a gel that's applied onto the skin once a day. Side effects include skin irritation, redness, and peeling. Your acne might get worse at the beginning of treatment, but it should get better as you continue using the medication. You must have a prescription for Retin-A (tretinoin) from your primary care provider or dermatologist; this medication isn't available over the counter.

Indications for Tretinoin

  • Acne

Pros and Cons for Tretinoin

Pros

  • Easy to apply onto your skin
  • Only need to apply once nightly
  • Available in a lower-cost generic form

Cons

  • Makes your skin more sensitive to sunlight, which can lead to sunburns
  • Can cause your skin color to temporarily become lighter or darker
  • Might worsen your acne during the first few weeks of treatment

Common Side Effects for Tretinoin

  • Skin peeling or discomfort
  • Warm feeling or stinging after applying
  • Skin redness
  • Sensitivity to sunlight (sunburns)
  • Worsening of acne in the first few weeks of treatment

Warnings for Tretinoin

  • Sunburns
  • Skin irritation in extreme weather
  • Skin reactions

Prices with our coupons for Arazlo vs. Tretinoin

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Arazlo1 tube / 45g of 0.045%
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Tretinoin1 tube / 45g of 0.025%
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