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Alka-Seltzer vs. Prevacid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Alka-Seltzer (citric acid/aspirin/sodium bicarbonate) and lansoprazole (Prevacid) are both used to treat heartburn, but they work in different ways and are used for different conditions. Alka-Seltzer combines antacids and aspirin to quickly neutralize stomach acid and relieve pain, making it suitable for short-term relief of heartburn, indigestion, and headaches. It is available over-the-counter and is taken as needed, typically every 4 to 6 hours. However, it contains aspirin, which can cause stomach bleeding and is not recommended for children under 12 or pregnant women. On the other hand, lansoprazole (Prevacid) is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used for longer-term treatment of conditions like gastroesophageal reflux disease (GERD), stomach ulcers, and erosive esophagitis. Lansoprazole is available both over-the-counter and by prescription, and it is usually taken once daily. It takes a few days to start working and is not suitable for immediate relief. Long-term use of Lansoprazole can lead to risks like bone fractures and low magnesium levels. Unlike Alka-Seltzer, lansoprazole does not contain aspirin.

Alka-Seltzer

 

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Lansoprazole

(Prevacid)

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Summary for Alka-Seltzer

Over-the-counter

Alka-Seltzer is a medication used to treat symptoms of heartburn, such as upset stomach and headache. While there are multiple products under this brand, this page focuses on the combination medication containing 3 active ingredients: citric acid, sodium bicarbonate, and aspirin. It comes as tablets that are dissolved in water. You drink the mixture by mouth, typically every 4-6 hours as needed.

Indications for Alka-Seltzer

  • Heartburn, indigestion, and sour stomach with headache, body aches, or pain
  • Upset stomach and headache from having too much food or drink
  • Headache, body aches, and pain alone

Pros and Cons for Alka-Seltzer

Pros

  • Combination of three medications in a single pill
  • Easy to take for people who have trouble swallowing pills
  • Available over the counter

Cons

  • Might not be safe for children 12 years old and younger
  • Might need to take multiple times per day
  • Might not be safe for people with certain health conditions (e.g. kidney problems, heart problems, high bleeding risk)

Common Side Effects for Alka-Seltzer

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Warnings for Alka-Seltzer

  • Stomach bleeding and ulcers
  • Reye's syndrome in children
  • Allergic reactions

Summary for Prevacid

Prescription or over-the-counter

Lansoprazole (Prevacid) a proton-pump inhibitor (PPI). It treats heartburn, gastroesophageal reflux disease (GERD), and other similar conditions by lowering the amount of acid produced in the stomach. Lansoprazole (Prevacid) is available over the counter (OTC) for adults only, while providers can prescribe lansoprazole (Prevacid) for children and adults. Lansoprazole (Prevacid) is taken by mouth, typically once daily for most conditions. Although there aren't many noticeable side effects on a day-to-day basis, long-term use of lansoprazole (Prevacid) can raise certain risks like bone fractures.

Indications for Prevacid

For adults only:

For adults and children:

Pros and Cons for Prevacid

Pros

  • Can continue to use with antacids, such as calcium carbonate
  • Available as over-the-counter and lower-cost generic options
  • Capsules can be opened and sprinkled over soft foods (e.g., applesauce, yogurt)
  • Typically few to no noticeable day-to-day side effects

Cons

Common Side Effects for Prevacid

  • Diarrhea (4%)
  • Belly pain (2%)

Warnings for Prevacid

  • Risk of hiding symptoms of a more serious problem
  • Sudden kidney problems
  • Severe infectious diarrhea
  • Bone fractures
  • Skin reactions
  • Lupus
  • Low vitamin B12 and magnesium levels
  • Interaction with other medications
  • Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

Prices with our coupons for Alka-Seltzer vs. Prevacid

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Alka-Seltzer1 carton / 2 effervescent tablets of 1000mg/325mg/1916mg
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Lansoprazole30 capsules / 30mg
$12.53$35.13
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