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Aklief vs. Arazlo

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Aklief

(trifarotene)

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Arazlo

(tazarotene)

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Summary for Aklief

Prescription only

Aklief contains trifarotene 0.005% topical cream. It's a retinoid used to treat acne in people ages 9 years and older. Aklief (trifarotene) is applied directly to the affected area(s) once per day in the evening. Some of the more common effects include dry skin, peeling, and itching. Your skin will likely experience more irritation during the first month of treatment, before it starts to improve.

Indications for Aklief

  • Treatment of acne in people ages 9 years and older

Pros and Cons for Aklief

Pros

  • Available as a cream in an easy-to-use pump
  • Only need to use once per day
  • Treats acne on the face, chest, shoulders, and back
  • Safe to use in children ages 9 years and older

Cons

  • Only available as a brand-name medication
  • Skin might look worse during the first month of treatment, before it starts to improve
  • Can make your skin more sensitive to sunlight, which can lead to sunburns
  • Must use mild, non-medicated soaps, cleansers, and shampoos to prevent skin irritation

Common Side Effects for Aklief

  • Irritation at application site (8%)
  • Sunburn (3%)
  • Skin itching (2%)

Warnings for Aklief

  • Skin irritation
  • Sunburn

Summary for Arazlo

Prescription only

Arazlo, the brand name for tazarotene 0.045% lotion, is a retinoid that's approved for treating acne. It can be prescribed for people ages 9 years and older. This medication is applied directly to the affected areas of skin once per day. Side effects include dry skin and skin pain (such as burning or stinging). It also can raise your risk for sunburns. Even though Arazlo (tazarotene) is applied directly to the skin, it's not safe to use while pregnant.

Indications for Arazlo

Pros and Cons for Arazlo

Pros

  • A first-choice option for treating acne
  • Only applied once a day
  • Approved for children as young as 9 years old

Cons

  • Can make you sunburn more easily
  • Available by prescription only
  • Not safe to use while pregnant

Common Side Effects for Arazlo

  • Stinging, burning, or pain on the skin (5%)
  • Dry skin (4%)

Warnings for Arazlo

  • Harm to unborn baby
  • Skin irritation
  • Risk for sunburn

Prices with our coupons for Aklief vs. Arazlo

Price Card Drug Icon
Aklief1 pump / 45g of 0.005%
$613.13$921.80
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Price Card Drug Icon
Arazlo1 tube / 45g of 0.045%
$538.42$679.22
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