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Abilify vs. Lexapro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Aripiprazole (Abilify) and escitalopram (Lexapro) are both medications used to treat mental health conditions, but they belong to different medication classes. Aripiprazole is an atypical antipsychotic used for conditions like schizophrenia, bipolar I disorder, and as an add-on for depression, while escitalopram is a selective serotonin reuptake inhibitor (SSRI) primarily used for depression and generalized anxiety disorder (GAD). Aripiprazole is available in various forms, including tablets, orally disintegrating tablets, and oral solutions, and is taken once daily. Escitalopram is available as a tablet and oral solution and is also taken once daily. Both medications are available in a lower-cost generic. Common side effects of aripiprazole include headache, agitation, and trouble sleeping, whereas escitalopram may cause nausea, trouble sleeping, and dizziness. Both can interact with a number of other medications, so be sure your prescriber and pharmacist have a complete list of your medications.

Aripiprazole

(Abilify)

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Escitalopram

(Lexapro)

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Summary for Abilify

Prescription only

Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder. It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) that can be used in adults and children as young as 6 years old for certain conditions. Common side effects include headache, movement problems, and sleep problems.

Indications for Abilify

Pros and Cons for Abilify

Pros

Cons

  • Can make you feel restless
  • Risk of movement problems that can be permanent
  • Can raise blood sugar and cholesterol
  • Can take several weeks to see the full effects

Common Side Effects for Abilify

  • Headache (27%)
  • Agitation (19%)
  • Trouble sleeping (18%)
  • Anxiety (17%)
  • Nausea (15%)
  • Vomiting (11%)
  • Constipation (11%)
  • Dizziness (10%)
  • Trouble staying still (10%)

Note: Side effects were reported by adults who took aripiprazole in clinical studies for schizophrenia and bipolar disorder.

Warnings for Abilify

  • Higher risk of death in older adults with dementia-related psychosis
  • Neuroleptic malignant syndrome
  • High blood sugar, high cholesterol, and weight gain
  • Difficulty controlling movements
  • Changes in blood pressure and higher risk of falls
  • Risk of infection (from low white blood cell count)
  • Difficulty concentrating and extreme sleepiness
  • Seizures
  • Impulse-control problems

Summary for Lexapro

Prescription only

Escitalopram, also known by its brand name, Lexapro, is a selective serotonin reuptake inhibitor (SSRI). It's a first-choice antidepressant to treat depression and anxiety in adults and children. The medication is available as a tablet and oral solution, in both brand and generic forms. A dose is typically taken by mouth once per day. Some common side effects include nausea, trouble sleeping (insomnia), and dizziness.

Indications for Lexapro

Pros and Cons for Lexapro

Pros

  • First-choice medication for anxiety and depression
  • Only need to take it once a day
  • Generally has fewer side effects compared to other antidepressants
  • Can be taken with or without food

Cons

  • Can take up to 2 months before you feel the the full benefits
  • Risk of certain sexual problems
  • Can raise your risk for bleeds
  • Can cause withdrawal symptoms if you suddenly stop taking it

Common Side Effects for Lexapro

  • Headache (24%)
  • Nausea (15-18%)
  • Ejaculation problems (9-14%)
  • Sleepiness (6-13%)
  • Trouble sleeping (9-12%)
  • Dry mouth (6-9%)
  • Diarrhea (8%)
  • Tiredness (5-8%)

Warnings for Lexapro

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Stopping escitalopram (Lexapro) too suddenly
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Low blood sodium levels
  • Sexual problems

Prices with our coupons for Abilify vs. Lexapro

Price Card Drug Icon
Aripiprazole30 tablets / 5mg
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Escitalopram30 tablets / 10mg
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