Antihistamines are used to treat allergic conjunctivitis, allergic rhinitis, hives, anaphylaxis, skin allergies, insomnia, and nasal congestion. They work by blocking histamines which cause allergic reactions and by slowing down activity in the central nervous system.

Why are
Antihistamines
prescribed?

How is this chart calculated?

How we make this chart

This chart is created by aggregating the total number of claims for the drugs in this class divided by the # of drugs with a specific indication. It is meant to be representative but may not accurately reflect the actual # of prescriptions written to treat a specific condition.

Prices for Popular Antihistamines

Popularity Brand Name (Generic Name) GoodRx Fair Price Price Trend
hydroxyzine hydrochloride
119
See Prices
HYDROXYZINE is an antihistamine. This medicine is used to treat allergy symptoms. It is also used to treat anxiety and tension. This medicine can be used with other medicines to induce sleep before surgery.
Promethegan
(promethazine)
8
See Prices
PROMETHAZINE is an antihistamine. It is used to treat allergic reactions and to treat or prevent nausea and vomiting from illness or motion sickness. It is also used to make you sleep before surgery, and to help treat pain or nausea after surgery.
Phenadoz
(promethazine)
8
See Prices
PROMETHAZINE is an antihistamine. It is used to treat allergic reactions and to treat or prevent nausea and vomiting from illness or motion sickness. It is also used to make you sleep before surgery, and to help treat pain or nausea after surgery.
Vistaril
(hydroxyzine pamoate)
10
See Prices
HYDROXYZINE is an antihistamine. This medicine is used to treat allergy symptoms. It is also used to treat anxiety and tension. This medicine can be used with other medicines to induce sleep before surgery.
Claritin
(loratadine)
N/A N/A See Prices
Claritin (loratadine) is an over-the-counter antihistamine used to treat seasonal allergies. It works by blocking the action of histamine which causes allergic symptoms. Generic loratadine is also available over the counter.
Zyrtec
(cetirizine)
N/A N/A See Prices
Zyrtec (cetirizine) is an antihistamine used to treat seasonal allergies and hives. It is available over the counter, though children under six with hives will still need a prescription. A generic version of Zyrtec is also available over the counter, sold as cetirizine.
Astepro
(azelastine)
28
See Prices
AZELASTINE nasal spray is a histamine blocker. It helps to relieve itching, running and stuffiness in the nose. This medicine is used to treat nasal symptoms from allergies and other irritants.
Astelin
(azelastine)
28
See Prices
AZELASTINE nasal spray is a histamine blocker. It helps to relieve itching, running and stuffiness in the nose. This medicine is used to treat nasal symptoms from allergies and other irritants.
Optivar
(azelastine)
28
See Prices
AZELASTINE is an antihistamine. It is used in the eye to treat itching of eyes caused by hay fever or other allergies.
Xyzal
(levocetirizine)
12
See Prices
LEVOCETIRIZINE is an antihistamine. This medicine is used to treat or prevent symptoms of allergies. It is also used to help reduce itchy skin rash and hives.
Unisom
(doxylamine, diphenhydramine)
N/A N/A See Prices
Unisom (diphenhydramine or doxylamine) is an antihistamine used as an over-the-counter sleep aid. Antihistamines often cause drowsiness and sedation and can be used to help with difficult falling asleep. Unisom capsules and chewable tablets have diphenhydramine as an active ingredient, and the tablets have doxylamine; both are available as generic antihistamine sleep aids.
Diphenhist
(diphenhydramine)
N/A N/A See Prices
Diphenhist (diphenhydramine) is an antihistamine used to treat symptoms of seasonal allergies including sneezing, runny nose, and itching or watering eyes. It works by blocking the action of histamine which causes allergic symptoms. It is available over-the-counter, and also sold as generic diphenhydramine. Other brands include Benadryl.
Zzzquil
(diphenhydramine)
N/A N/A See Prices
ZzzQuil (diphenhydramine) is an antihistamine used as an over-the-counter sleep aid. Antihistamines often cause drowsiness and sedation and can be used to help with difficult falling asleep. ZzzQuil includes only the sleep-aid active ingredient from NyQuil, without the other ingredients to treat cough and cold symptoms. Diphenhydramine is also available as a generic, and under other brand names including Benadryl and Unisom.
Benadryl
(diphenhydramine)
N/A N/A See Prices
Benadryl (diphenhydramine) is an antihistamine used to treat symptoms of seasonal allergies including sneezing, runny nose, and itching or watering eyes. It works by blocking the action of histamine which causes allergic symptoms. It is available over-the-counter, and also sold as generic diphenhydramine.
Allegra
(fexofenadine)
N/A N/A See Prices
Allegra (fexofenadine) is an antihistamine used to treat seasonal allergies and hives. It is available over the counter, though children under six with hives will still need a prescription. A generic version of Allegra is also available over the counter, sold as fexofenadine.
cetirizine prescription
9
See Prices
CETIRIZINE is an antihistamine. This medicine is used to treat or prevent symptoms of allergies. It is also used to help reduce itchy skin rash and hives.
cyproheptadine
15
See Prices
CYPROHEPTADINE is a antihistamine. This medicine is used to treat allergy symptoms. It is can help stop runny nose, watery eyes, and itchy rash.
Patanol
(olopatadine)
47
See Prices
OLOPATADINE drops are used in the eye to treat symptoms caused by allergies.
Patanase
(olopatadine)
47
See Prices
OLOPATADINE is a histamine blocker. It helps to relieve itching, running, and stuffiness in the nose. This medicine is used to treat nasal symptoms from allergies and other irritants.
Pataday
166
See Prices
OLOPATADINE drops are used in the eye to treat symptoms caused by allergies.
Children's Claritin
(children's loratadine)
N/A N/A See Prices
LORATADINE is an antihistamine. It helps to relieve sneezing, runny nose, and itchy, watery eyes. This medicine is used to treat the symptoms of allergies. It is also used to treat itchy skin rash and hives.
Clarinex
(desloratadine)
28
See Prices
DESLORATADINE is an antihistamine. It helps to relieve sneezing, runny nose, and itchy, watery eyes. This medicine is used to treat or prevent symptoms of allergies. It is also used to treat itchy skin rash and hives.
Ketotifen
N/A N/A See Prices
KETOTIFEN eye drops are used in the eye to prevent itching that is caused by allergies.
Pazeo
172
See Prices
OLOPATADINE drops are used in the eye to treat symptoms caused by allergies.
Children's Diphenhist
(children's diphenhydramine)
N/A N/A See Prices
DIPHENHYDRAMINE is an histamine blocker. It is used to treat the symptoms of an allergic reaction.
Children's Zyrtec
(children's cetirizine)
N/A N/A See Prices
Children's Zyrtec (cetirizine) is an antihistamine used to treat seasonal allergies and hives. It is available over the counter, though children under six with hives will still need a prescription. Generic Children's Zyrtec is also available over the counter, sold as children's cetirizine.
loratadine / pseudoephedrine
N/A N/A See Prices
Loratadine/pseudoephedrine is an antihistamine combined with the same active ingredient as Sudafed. It is used to treat seasonal allergies and relieve nasal congestion and sinus pressure. It is sold over the counter, and also available as brand name Claritin-D.
Elestat
(epinastine)
56
See Prices
EPINASTINE is an antihistamine for use in the eye. It is used to prevent itching of the eye caused by allergies.
q-dryl
N/A N/A See Prices
DIPHENHYDRAMINE is an histamine blocker. It is used to treat the symptoms of an allergic reaction.
Alaway
N/A N/A See Prices
KETOTIFEN eye drops are used in the eye to prevent itching that is caused by allergies.
Children's Benadryl
(children's diphenhydramine)
N/A N/A See Prices
DIPHENHYDRAMINE is an histamine blocker. It is used to treat the symptoms of an allergic reaction.
Bepreve
180
See Prices
BEPOTASTINE drops are used in the eye to treat itching caused by allergies.
Arbinoxa
(carbinoxamine maleate)
40
See Prices
CARBINOXAMINE is an antihistamine. It is used to treat the symptoms of allergies and hives.
Palgic
(carbinoxamine maleate)
40
See Prices
CARBINOXAMINE is an antihistamine. It is used to treat the symptoms of allergies and hives.
clemastine
30
See Prices
CLEMASTINE is an antihistamine. It is used to treat the symptoms of allergies and mild allergic reactions. This medicine will not treat an infection.
Lastacaft
187
See Prices
Alcaftadine (Lastacaft) is an expensive drug used to prevent itching of the eye caused by allergies. This drug is less popular than comparable drugs. there are currently no generic alternatives to Lastacaft. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Children's Allegra
(children's fexofenadine)
N/A N/A See Prices
Children's Allegra (fexofenadine) is an antihistamine used to treat seasonal allergies and hives. It is available over the counter, though children under six with hives will still need a prescription. Lower-dose orally disintegrating tablets and and oral suspension may be easier for children to take. A generic version of Children's Allegra is also available over the counter, sold as children's fexofenadine.
Zaditor
N/A N/A See Prices
KETOTIFEN eye drops are used in the eye to prevent itching that is caused by allergies.
Dramamine
(dimenhydrinate)
N/A N/A See Prices
DIMENHYDRINATE is an antihistamine. It is used to prevent and to treat the nausea, vomiting, or dizziness of motion sickness.
Dimetapp
N/A N/A See Prices
Emadine
129
See Prices
EMEDASTINE is an antihistamine for use in the eye. It is used to prevent itching of the eye caused by allergies.
Tavist Allergy
(clemastine non-prescription)
N/A N/A See Prices
CLEMASTINE is an antihistamine. It is used to treat the symptoms of allergies and mild allergic reactions. This medicine will not treat an infection.
Dec-Chlorphen
N/A N/A See Prices
dexchlorpheniramine
1,000,000
See Prices
Dramamine For Kids
N/A N/A See Prices
DIMENHYDRINATE is an antihistamine. It is used to prevent and to treat the nausea, vomiting, or dizziness of motion sickness.

Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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