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Triprolidine

Generic Histex PD
Used for Allergic Rhinitis

Triprolidine is an over-the-counter antihistamine. It's used to relieve allergy symptoms, such as runny nose, sneezing, and watery eyes for both children and adults. This medication comes as a liquid that's taken by mouth every 4 to 6 hours. Some side effects you might experience from triprolidine include sleepiness, dizziness, and blurry vision.

Reviewed by:Last reviewed on September 5, 2023
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What is Triprolidine?

What is Triprolidine used for?

  • Short-term relief of allergy symptoms (e.g., runny nose, sneezing, itching of the nose or throat, watery eyes)

How Triprolidine works

Triprolidine is a first-generation antihistamine. It blocks histamine, a natural chemical in your body that can cause allergy symptoms like itchiness, itchy eyes, or runny nose. By blocking histamine, triprolidine helps relieve allergy symptoms.

Drug facts

Common BrandsHistex, Histex PD, Miclara LQ
Drug ClassAntihistamine
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
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Side effects of Triprolidine

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness
  • Feeling unsteady on your feet
  • Dizziness
  • Blurry vision
  • Dry mouth

Less Common Side Effects

  • Confusion
  • Upset stomach
  • Constipation
  • Headache

Triprolidine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Excessive sleepiness or dizziness
  • Accidentally taking too much medication: fast heartbeat, flushing, extreme sleepiness, hallucinations, changes in vision, irritability in children

Source: DailyMed

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$78.12(Save 87.51%)
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Pros and cons of Triprolidine

Pros

  • Can be used in children as young as 6 years old (if younger, ask your child's provider first)
  • Good option for people who can't or don't prefer to take pills by mouth
  • Available as a lower-cost generic

Cons

  • Can make you feel sleepy or dizzy
  • Can cause hyperactivity in some children
  • Not the best choice for people over 65 years old or people with glaucoma, breathing problems, or urinary problems
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Pharmacist tips for Triprolidine

pharmacist
  • Take triprolidine with or without food. If it hurts your stomach, try taking it with food to help.
  • Use a medication dose cup or an oral syringe to measure your dose of triprolidine. Ask your pharmacy to provide you with one if the product doesn't include it in its packaging or if you need extras. Don't use household spoons because they might not be accurate and might cause you to take the wrong dose.
  • Triprolidine can make you sleepy and dizzy. Don't drive until you know how this medication affects you. It's best to avoid drinking alcohol while taking this medication because it can make sleepiness and dizziness worse.
  • While triprolidine can make adults feel sleepy, this medication can sometimes make children feel overly-excited or energetic. If this happens to your child, speak to your child's provider. They can recommend other allergy medications for your child.
  • Tell your provider or pharmacist about all the medications you're taking, including over-the-counter medications and supplements, to make sure triprolidine is safe for you. Don't start any new medications while taking triprolidine, especially other antihistamines, without talking to your provider or pharmacist first. Doing so can raise your risk of overdose and serious side effects, including confusion and extreme sleepiness.
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Risks and warnings for Triprolidine

Triprolidine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Sleepiness

  • Risk factors: Drinking alcohol | Taking other medications that cause sleepiness | Age 65 and older

Triprolidine can make you sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're over 65 years old, drink alcohol while taking triprolidine, or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). It's best to avoid alcohol and other medications that might make you sleepy while taking triprolidine. Don't drive or operate machinery until you know how this medication affects you.

Worsening of medical conditions

  • Risk factors: Glaucoma | Urinary problems (e.g., large prostate gland, bladder neck blockage) | Breathing problems (e.g., emphysema or long-term bronchitis)

Don't take triprolidine if you have any of the risk factors listed above unless your provider said it's safe to do so. Taking this medication can worsen your condition(s) and cause serious side effects. Make sure your provider knows about all medical conditions you have or have had in the past before starting triprolidine.

Accidental overdose

Triprolidine is an antihistamine, which is in many other over-the-counter products. Taking more than one medication containing an antihistamine can lead to serious side effects, such as blurry vision, reddening of skin, and confusion.

Don't start any new medications while taking triprolidine without talking to your provider or pharmacist first. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine, ask your provider or pharmacist.

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Triprolidine dosage

The average cost for 1 dropper of 50ml of 1.25mg/2ml of Triprolidine is $10.67 with a free GoodRx coupon. This is 43.63% off the average retail price of $18.93.
dropperDropper
DosageQuantityPrice as low asPrice per unit
30ml of 0.625mg/ml1 dropper$9.76$9.76
30ml of 0.938mg/ml1 dropper$11.64$11.64
50ml of 1.25mg/2ml1 dropper$10.67$10.67

Typical dosage for Triprolidine

Triprolidine products come in different concentrations, meaning they can differ in the dosage of triprolidine per milliliter (mL) of liquid. Follow the manufacturer's direction on the label for specific dosing instructions for your product.

In general:

  • Adults and children ages 12 years or older: The typical dose is to take 2.5 mg by mouth every 4 to 6 hours. Don't take more than 10 mg in 24 hours, unless directed by your provider.
  • Children ages 6 to under 12 years old: The typical dose is to take 1.25 mg by mouth every 4 to 6 hours. Don't take more than 5 mg in 24 hours, unless directed by your provider.
  • Children ages 6 years and under: Ask your child's provider.
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How much does Triprolidine cost?

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What are alternatives to Triprolidine?

There are a number of medications that your doctor can prescribe in place of Triprolidine. Compare a few possible alternatives below.
Triprolidine
Used for:
  • Short-term relief of allergy symptoms (e.g., runny nose, sneezing, itching of the nose or throat, watery eyes)
$9.76Lowest GoodRx priceView prices
Used for:
  • Short-term relief of allergy or common cold symptoms (runny nose, sneezing, itchy nose or throat, and itchy or watery eyes) - people 6 years and older
  • Occasional trouble sleeping - people 12 years and older
$4.09Lowest GoodRx priceView prices
Used for:
  • Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
  • Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only
$8.70Lowest GoodRx priceView prices

References

Best studies we found

Borowy, C. S., et al. (2023). Antihistamine toxicity. StatPearls.

Brandywine Pharmaceuticals, LLC. (2024). Triprolidine HCL drops- triprolidine hydrochloride liquid [package insert]. DailyMed.

Drugs and Lactation Database (LactMed®). Triprolidine. National Institute of Child Health and Human Development.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.