Doxylamine succinate (Unisom SleepTabs) is an over-the-counter antihistamine that can be taken by adults and children ages 12 years and older who are having trouble falling asleep. It's a sleep aid that works by blocking certain chemicals (histamine) in your body. Doxylamine (Unisom SleepTabs) is taken by mouth once a day, about 30 minutes before bedtime. The most common side effect of this medication is next-day sleepiness.
Doxylamine (Unisom SleepTabs) is an antihistamine. It blocks histamine, a natural chemical in your body and brain. By blocking histamine in the brain, it causes sleepiness.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Doxylamine (Unisom SleepTabs) is generally safe to take. But it might not be the best choice for older adults ages 65 years of age or older because they're at higher risk for side effects, like dizziness, confusion, and next-day sleepiness. In addition, doxylamine (Unisom SleepTabs) might not be right for people who've certain medical conditions, such as breathing problems (e.g., emphysema or bronchitis), glaucoma, or trouble urinating due to an enlarged prostate. This is because doxylamine (Unisom SleepTabs) might worsen the symptoms of these conditions. Talk to your provider if you're not sure if doxylamine (Unisom SleepTabs) is safe for you.
Doxylamine (Unisom SleepTabs) usually starts to work 30 minutes after you take it. This is why you should take it at least half an hour before trying to go to sleep.
The recommended dose of doxylamine (Unisom SleepTabs) is 25 mg by mouth at night. If this dose isn't working well enough to help you sleep, talk with your provider. They can help you figure out what might be causing your sleep problems, and let you know about other treatment options and lifestyle tips to help you sleep.
No, it's best to avoid drinking alcohol while taking doxylamine (Unisom SleepTabs) because doing so raises your risk for severe sleepiness and dizziness. If you drink alcohol regularly and have a hard time stopping completely, talk with your provider what's a safer amount to drink. They can also talk with you about other options to ease your sleep problems, including lifestyle tips.
Yes, doxylamine (Unisom SleepTabs) is a first-generation antihistamine, which is a class of medications known to cause sleepiness. Doxylamine (Unisom SleepTabs) helps you sleep by blocking histamine in the brain.
Yes, first-generation antihistamines like doxylamine (Unisom SleepTabs), are a safe option during pregnancy. In fact, doxylamine is present in a combination medication called Diclegis (doxylamine / pyridoxine) that's used to ease nausea during pregnancy.
No, you shouldn't take diphenhydramine (Benadryl) and doxylamine (Unisom SleepTabs) together because they're both antihistamines. Taking more than one antihistamine raises your risk for serious side effects without additional benefit. Talk to your pharmacist or provider if you're not sure which medication is best for you.
Doxylamine (Unisom SleepTabs) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Doxylamine (Unisom SleepTabs) can make you sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're over 65 years old, drink alcohol while taking doxylamine (Unisom SleepTabs), or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). It's best to avoid alcohol and other medications that might make you sleepy while taking doxylamine (Unisom SleepTabs). Don't drive or operate machinery until you know how this medication affects you.
Don't take doxylamine (Unisom SleepTabs) if you have any of the risk factors listed above unless your provider said it's safe to do so. Taking this medication can worsen your condition(s) and cause serious side effects. Make sure your provider knows about all medical conditions you have or have had in the past before starting doxylamine (Unisom SleepTabs).
Doxylamine (Unisom SleepTabs) is an antihistamine, which is in many other over-the-counter products. Taking more than one medication containing an antihistamine can lead to serious side effects, such as blurry vision, reddening of skin, and confusion.
Don't start any new medications while taking doxylamine (Unisom SleepTabs) without talking to your provider or pharmacist first. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine, ask your provider or pharmacist.
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 25mg | 30 tablets | $4.86 | $0.16 |