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doxylamine

Generic Unisom
Used for Insomnia

Doxylamine succinate (Unisom SleepTabs) is an over-the-counter antihistamine that can be taken by adults and children ages 12 years and older who are having trouble falling asleep. It's a sleep aid that works by blocking certain chemicals (histamine) in your body. Doxylamine (Unisom SleepTabs) is taken by mouth once a day, about 30 minutes before bedtime. The most common side effect of this medication is next-day sleepiness.

Reviewed by:Last reviewed on October 2, 2023
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What is Doxylamine (Unisom SleepTabs)?

What is Doxylamine (Unisom SleepTabs) used for?

How Doxylamine (Unisom SleepTabs) works

Doxylamine (Unisom SleepTabs) is an antihistamine. It blocks histamine, a natural chemical in your body and brain. By blocking histamine in the brain, it causes sleepiness.

When does Doxylamine (Unisom SleepTabs) start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsUnisom SleepTabs
Drug ClassAntihistamine
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
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Side effects of Doxylamine (Unisom SleepTabs)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

  • Constipation
  • Trouble urinating
  • Urinary retention
  • Blurry or double vision

Doxylamine (Unisom SleepTabs) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Excessive sleepiness or dizziness
  • Accidentally taking too much medication: fast heartbeat, flushing, extreme sleepiness, hallucinations, changes in vision, irritability in children
When do Doxylamine (Unisom SleepTabs) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Sleepiness
Dizziness

Source: DailyMed

The following Doxylamine (Unisom SleepTabs) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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Pros and cons of Doxylamine (Unisom SleepTabs)

Pros

  • Works well to help you fall asleep
  • Available over the counter and as a lower-cost generic
  • Starts to work quickly (within 1 hour)
  • Can be used in children as young as 12 years old

Cons

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Pharmacist tips for Doxylamine (Unisom SleepTabs)

pharmacist
  • After you take doxylamine (Unisom SleepTabs), this medication can continue to make you feel sleepy throughout the next day. Only take doxylamine (Unisom SleepTabs) if you have time for a full night's sleep.
  • Don't drive or do anything that needs a lot of focus until you know how doxylamine (Unisom SleepTabs) affects you. It's best to avoid drinking alcohol while taking this medication because it can make sleepiness and dizziness worse.
  • Stop taking doxylamine (Unisom SleepTabs) and contact your provider if you're still having trouble sleeping after taking the medication for 2 weeks. This could be a sign of a more serious medical problem.
  • Tell your provider or pharmacist about all the medications you're taking, including over-the-counter medications and supplements, to make sure doxylamine (Unisom SleepTabs) is safe for you. Don't start any new medications while taking doxylamine (Unisom SleepTabs), especially other antihistamines, without talking to your provider or pharmacist first. Doing so can raise your risk of serious side effects, including confusion and extreme sleepiness.
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Common questions about Doxylamine (Unisom SleepTabs)

Doxylamine (Unisom SleepTabs) is generally safe to take. But it might not be the best choice for older adults ages 65 years of age or older because they're at higher risk for side effects, like dizziness, confusion, and next-day sleepiness. In addition, doxylamine (Unisom SleepTabs) might not be right for people who've certain medical conditions, such as breathing problems (e.g., emphysema or bronchitis), glaucoma, or trouble urinating due to an enlarged prostate. This is because doxylamine (Unisom SleepTabs) might worsen the symptoms of these conditions. Talk to your provider if you're not sure if doxylamine (Unisom SleepTabs) is safe for you.

Doxylamine (Unisom SleepTabs) usually starts to work 30 minutes after you take it. This is why you should take it at least half an hour before trying to go to sleep.

The recommended dose of doxylamine (Unisom SleepTabs) is 25 mg by mouth at night. If this dose isn't working well enough to help you sleep, talk with your provider. They can help you figure out what might be causing your sleep problems, and let you know about other treatment options and lifestyle tips to help you sleep.

No, it's best to avoid drinking alcohol while taking doxylamine (Unisom SleepTabs) because doing so raises your risk for severe sleepiness and dizziness. If you drink alcohol regularly and have a hard time stopping completely, talk with your provider what's a safer amount to drink. They can also talk with you about other options to ease your sleep problems, including lifestyle tips.

Yes, doxylamine (Unisom SleepTabs) is a first-generation antihistamine, which is a class of medications known to cause sleepiness. Doxylamine (Unisom SleepTabs) helps you sleep by blocking histamine in the brain.

Yes, first-generation antihistamines like doxylamine (Unisom SleepTabs), are a safe option during pregnancy. In fact, doxylamine is present in a combination medication called Diclegis (doxylamine / pyridoxine) that's used to ease nausea during pregnancy.

No, you shouldn't take diphenhydramine (Benadryl) and doxylamine (Unisom SleepTabs) together because they're both antihistamines. Taking more than one antihistamine raises your risk for serious side effects without additional benefit. Talk to your pharmacist or provider if you're not sure which medication is best for you.

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Risks and warnings for Doxylamine (Unisom SleepTabs)

Doxylamine (Unisom SleepTabs) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Extreme sleepiness

  • Risk factors: Drinking alcohol | Taking other medications that cause sleepiness | Age 65 and older

Doxylamine (Unisom SleepTabs) can make you sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're over 65 years old, drink alcohol while taking doxylamine (Unisom SleepTabs), or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). It's best to avoid alcohol and other medications that might make you sleepy while taking doxylamine (Unisom SleepTabs). Don't drive or operate machinery until you know how this medication affects you.

Worsening of medical conditions

  • Risk factors: Glaucoma | Urinary problems (e.g., large prostate gland, bladder neck blockage) | Breathing problems (e.g., emphysema or long-term bronchitis)

Don't take doxylamine (Unisom SleepTabs) if you have any of the risk factors listed above unless your provider said it's safe to do so. Taking this medication can worsen your condition(s) and cause serious side effects. Make sure your provider knows about all medical conditions you have or have had in the past before starting doxylamine (Unisom SleepTabs).

Accidental overdose

Doxylamine (Unisom SleepTabs) is an antihistamine, which is in many other over-the-counter products. Taking more than one medication containing an antihistamine can lead to serious side effects, such as blurry vision, reddening of skin, and confusion.

Don't start any new medications while taking doxylamine (Unisom SleepTabs) without talking to your provider or pharmacist first. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has an antihistamine, ask your provider or pharmacist.

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Doxylamine (Unisom SleepTabs) dosage

The average cost for 30 tablets of 25mg of Doxylamine (Unisom SleepTabs) is $4.86 with a free GoodRx coupon. This is 44.96% off the average retail price of $8.83.
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DosageQuantityPrice as low asPrice per unit
25mg30 tablets$4.86$0.16

Typical dosage for Doxylamine (Unisom SleepTabs)

  • Age 12 years and older: The typical dose is 25 mg by mouth once nightly, about 30 minutes before bedtime or as directed by your provider.
  • Age under 12 years old: Ask your child's provider.
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What are alternatives to Doxylamine (Unisom SleepTabs)?

There are a number of medications that your doctor can prescribe in place of Doxylamine (Unisom SleepTabs). Compare a few possible alternatives below.
Doxylamine (Unisom SleepTabs)
Used for:
$4.86Lowest GoodRx priceView prices
Used for:
  • Allergies
  • Common cold symptoms
  • Trouble sleeping for people 12 years and older
$2.52Lowest GoodRx priceView prices
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Doxylamine (Unisom SleepTabs) images

Blue Oval L441 - GoodSense Sleep Aid 25mg Tablet
This medicine is Blue, Oval, Scored Tablet Imprinted With "L441".Blue Oval L441 - GoodSense Sleep Aid 25mg Tablet
Purple Oval 15N - GoodSense Nighttime Sleep Aid Ultra 25mg Tablet (Berry)
This medicine is Purple, Oval Tablet Imprinted With "15N".Purple Oval 15N - GoodSense Nighttime Sleep Aid Ultra 25mg Tablet (Berry)
Purple Oval 15N - GoodSense Nighttime Sleep Aid Ultra 25mg Tablet (Berry)
This medicine is Purple, Oval Tablet Imprinted With "15N".Purple Oval 15N - GoodSense Nighttime Sleep Aid Ultra 25mg Tablet (Berry)
blue oblong - Wal-Som 25mg Tablet
This medicine is Blue, Oblong, Scored Tablet.blue oblong - Wal-Som 25mg Tablet
Blue Oblong L441 - CVS Nighttime Sleep Aid 25mg Tablet
This medicine is Blue, Oblong, Scored Tablet Imprinted With "L441".Blue Oblong L441 - CVS Nighttime Sleep Aid 25mg Tablet
Blue Oval 44 And 386 - Foster & Thrive Sleep Aid 25mg Tablet
This medicine is Blue, Oval Tablet Imprinted With "44" And "386".Blue Oval 44 And 386 - Foster & Thrive Sleep Aid 25mg Tablet

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References

Best studies we found

Brott, N. R., et al. (2023). Doxylamine. StatPearls.

Chattem, Inc. (2023). Unisom SleepTabs- doxyalmine succinate tablet [package insert]. DailyMed.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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