The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low blood sugar (up to 16%)
- Urinary tract infection (up to 9%)
- Upper respiratory tract infection or common cold (up to 8%)
Note: Side effect percentages were reported by adults taking empagliflozin, metformin, and a sulfonylurea.
Less Common Side Effects
- Vaginal yeast infection in females
- Genital fungal infection in males
- Joint pain
- More urination
- Nausea
- Vomiting
- Diarrhea
- Excessive gas
- Belly discomfort
- Indigestion
- Lack of energy
- Headache
Synjardy serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Buildup of lactic acid: confusion, feeling weak or tired, fast heartbeat, rapid breathing, no appetite, nausea, vomiting, stomach pain, muscle pain
- Ketoacidosis (high ketone levels in the blood): shortness of breath, vomiting, belly pain, dry skin, dry mouth, feeling very tired, fruity-smelling breath
- Sudden kidney problems: urinating less than usual
- Low blood pressure: dizziness, lightheadedness, confusion
- Serious genital infection: pain, swelling, or redness in the genital area; fever; weakness
- Severe allergic reaction: rash, blisters, sores, trouble breathing, swelling
Source: DailyMed
The following Synjardy side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
- Diabetic ketoacidosis (DKA)—increased thirst or amount of urine, dry mouth, fatigue, fruity odor to breath, trouble breathing, stomach pain, nausea, vomiting
- Genital yeast infection—redness, swelling, pain, or itchiness, odor, thick or lumpy discharge
- High lactic acid level—muscle pain or cramps, stomach pain, trouble breathing, general discomfort and fatigue
- Infection or redness, swelling, tenderness, or pain in the genitals, or area from the genitals to the back of the rectum
- Low vitamin B12 level—pain, tingling, or numbness in the hands or feet, muscle weakness, dizziness, confusion, trouble concentrating
- New pain or tenderness, change in skin color, sores or ulcers, infection of the leg or foot
- Urinary tract infection (UTI)—burning when passing urine, passing frequent small amounts of urine, bloody or cloudy urine, pain in the lower back or sides
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
