The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Nausea (11-20%)
- Stomach pain (10-11%)
- Diarrhea (9-10%)
- Lower appetite (6-9%)
- Vomiting (6-8%)
- Constipation (5-6%)
Less Common Side Effects
- Bloating
- Indigestion
- Burping
- Passing gas
- Acid reflux
- Dizziness
- Hair loss
- Fast heart rate
Rybelsus serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Risk of thyroid tumors: lump in the neck, trouble breathing or swallowing, hoarseness
- Vision changes (diabetic retinopathy): vision loss, blurred vision, floaters, seeing dark spots, changes in how you see color
- Inflammation of the pancreas (pancreatitis): severe stomach or back pain that won't go away, with or without vomiting
- Low blood sugar (hypoglycemia): shaking, sweating, dizziness, confusion, blurred vision
- Kidney damage: changes in urination, swollen feet or ankles, tiredness, nausea
- Severe stomach problems: nausea, vomiting, diarrhea, bloating, heartburn
- Gallbladder problems: pain in the upper stomach, fever, yellowing of your skin or eyes, clay-colored stool
- Serious allergic reactions: trouble breathing, rash, hives, swollen face, fast heartbeat, dizziness
When do Rybelsus possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Nausea or vomiting
Diarrhea
Stomach pain
Low appetite
Pancreatitis
Gallbladder disease
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
Source: Prescribing Information
More on Rybelsus side effects
14 Side Effects of Semaglutide for Type 2 Diabetes and Weight Loss
Written by Zuri C. Hawkins-Jarrett, PharmD, MPH, BCPS
The following Rybelsus side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Change in vision
- Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
- Gallbladder problems—severe stomach pain, nausea, vomiting, fever
- Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
- Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
- Thyroid cancer—new mass or lump in the neck, pain or trouble swallowing, trouble breathing, hoarseness
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Diarrhea
- Loss of appetite
- Nausea
- Stomach pain
- Vomiting
