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Saxenda

Saxenda Side Effects

Kristianne Hannemann, PharmDCydnee Ng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Cydnee Ng, PharmD
Last reviewed on April 1, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults:

  • Nausea (39%)
  • Diarrhea (21%)
  • Constipation (19%)
  • Vomiting (16%)
  • Injection site reaction (e.g., redness, itching, rash; 14%)
  • Headache (14%)
  • Low blood sugar in people with Type 2 diabetes (13%)
  • Indigestion (10%)

Children 12 years and up:

  • Nausea (42%)
  • Vomiting (34%)
  • Diarrhea (22%)
  • Low blood sugar (15%)
  • Stomach inflammation (13%)
  • Dizziness (10%)

Less Common Side Effects

Adults:

  • Tiredness
  • Dizziness
  • Stomach pain
  • Acid reflux
  • Bloating
  • Burping

Children 12 years and up:

  • Fever
  • Stomach discomfort
  • Constipation
  • Tiredness
  • Injection site pain
  • Abnormal cholesterol levels

Saxenda serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Pancreas or gallbladder problems: stomach or back pain that won't go away, nausea, vomiting, fever
  • Low blood sugar: shaking, sweating, dizziness, confusion, anxiety, blurred vision, feeling very hungry
  • Kidney problems: changes how often you urinate, blood in your urine, swollen feet or ankles, lower appetite, muscle cramping
  • Serious allergic reaction: trouble breathing; hives; itching; swelling of your face, lips, tongue, or throat
When do Saxenda possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Nausea or vomiting
Diarrhea
Constipation
Indigestion
Dizziness

Source: DailyMed

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The following Saxenda side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Fast or irregular heartbeat
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
  • Thyroid cancer—new mass or lump in the neck, pain or trouble swallowing, trouble breathing, hoarseness

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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