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Padcev

Padcev Side Effects

Julia Lee, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on November 10, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Rash (54%)
  • Feeling very tired (50%)
  • Numbness, tingling, or pain in the hands and feet (peripheral neuropathy) (50%)
  • Hair loss (47%)
  • Not feeling as hungry (41%)
  • Lower white blood cell count (up to 41%)
  • Diarrhea (35%)
  • Itching (34%)
  • Higher blood sugar levels (33%)
  • Nausea (30%)

Less Common Side Effects

  • Fever
  • Constipation
  • Stomach pain
  • Muscle, bone, or joint pain
  • Dry eye
  • Dry skin
  • Taste changes
  • Bleeding
  • Lower weight
  • Urinary tract infection (UTI)
  • Changes in electrolyte levels or other lab values

Note: Side effects were reported by adults taking [[EDITOR|DRUG_DISPLAY_NAME]] by itself. They might differ if you’re taking it with other cancer medications.

Padcev serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious skin reactions: rash, feeling very itchy, skin redness, blistering or peeling skin
  • High blood sugar levels: feeling very hungry or thirsty, urinating often
  • Lung problems: cough, feeling like you can’t catch your breath
  • Eye problems: changes in vision
  • Irritation at the infusion site: pain, swelling, or redness around the infusion site

Source: DailyMed

The following Padcev side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dry cough, shortness of breath or trouble breathing
  • Eye pain, redness, irritation, or discharge with blurry or decreased vision
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Painful swelling, warmth, or redness of the skin, blisters or sores at the infusion site
  • Pain, tingling, or numbness in the hands or feet
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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