The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low white blood cell count (up to 73%)
- Nausea (72%)
- Lower hemoglobin levels (67%)
- Feeling very tired (55%)
- Lower platelet levels (48%)
- Higher liver enzyme levels (up to 46%)
- Vomiting (38%)
- Hair loss (37%)
- Constipation (32%)
- Low potassium levels (32%)
- Low appetite (31%)
- Diarrhea (30%)
- Muscle, bone, or joint pain (24%)
Less Common Side Effects
- Stomach pain
- Indigestion
- Mouth sores
- Weight loss
- Headache
- Dizziness
- Nosebleed
- Cough
- Shortness of breath
- Respiratory infection
- Numbness or tingling in the arms or legs
- Fever
- Rash
- Infusion reactions (e.g., chills, nausea, headache, flushing)
Note: Side effects were from people with breast cancer, NSCLC, or solid tumors. Side effects might differ for those with stomach or esophageal cancer.
Enhertu serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Lung problems: cough, having trouble catching your breath, wheezing, chest tightness, fever
- Low white blood cell count and infection: fever, chills, feeling generally unwell
- Lower heart function: cough, having trouble catching your breath, feeling tired or dizzy, swelling of your ankles or legs, sudden weight gain, irregular heartbeat
When do Enhertu possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Nausea or vomiting
Feeling very tired
Hair loss
Low blood cell counts
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
Source: DailyMed
The following Enhertu side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry cough, shortness of breath or trouble breathing
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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