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Enhertu

Enhertu Dosage

Julia Lee, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on December 2, 2025

Typical dosage for Enhertu

Enhertu is given by a healthcare professional as an infusion through the vein (IV).

The dose depends on your cancer and your weight. Your oncologist will help find the right dose for you.

  • Breast cancer, NSCLC, or solid tumors: The typical dose is 5.4 mg/kg given as an IV infusion once every 3 weeks. It's usually given on day 1 of each 21-day treatment cycle.

  • Stomach or esophageal cancer: The typical dose is 6.4 mg/kg given as an IV infusion once every 3 weeks. It's usually given on day 1 of each 21-day treatment cycle.

Your oncologist might lower your dose if you have serious side effects from the medication.

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