The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low platelets (58%)
- Higher liver enzyme levels (up to 57%)
- Low white blood cells (52%)
- Lower hemoglobin levels (51%)
- Higher blood sugar levels (48%)
- Tiredness (38%)
- Rash (30%)
- Swelling (28%)
- Nausea (23%)
- Muscle pain (23%)
Less Common Side Effects
- Diarrhea
- Constipation
- Stomach pain
- Vomiting
- Lower appetite
- Shortness of breath
- Itching
Zynlonta serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious skin reaction: blistering or peeling rash, severe sunburn
- Infection: temperature of 100.4 degrees Fahrenheit or higher, chills, severe fatigue, muscle aches, cough, sore throat, trouble breathing
- Bleeding (from having low platelet levels): frequent nose bleeds, unexplained bruising, blood in urine, blood in stool
- Fluid collecting around heart or lungs: trouble breathing, chest pain, irregular heartbeat
Source: DailyMed
The following Zynlonta side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Capillary leak syndrome—stomach or muscle pain, unusual weakness or fatigue, feeling faint or lightheaded, decrease in the amount of urine, swelling of the ankles, hands, or feet, trouble breathing
- Fast or irregular heartbeat, feeling faint or lightheaded, trouble breathing, sharp pain in the chest, back, shoulder, or stomach
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Skin reactions on sun-exposed areas
- Swelling of the ankles, hands, or feet, shortness of breath or trouble breathing, sudden weight gain
- Unusual bruising or bleeding
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Fatigue
- Muscle pain
- Nausea
- Skin rash
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