pregabalin
Pregabalin (Lyrica) helps treat nerve pain and fibromyalgia in adults. It can also be taken with other medications to help treat certain seizures in people 1 month and older. Pregabalin (Lyrica) comes as a capsule and oral solution in both brand-name and generic versions. The dosage depends on what condition you're treating, but it's usually taken by mouth 2 or 3 times a day. Common side effects include feeling dizzy and drowsy. This medication is a controlled substance and has interactions, like with alcohol and benzodiazepines.
What is Pregabalin (Lyrica)?
What is Pregabalin (Lyrica) used for?
Nerve pain from diabetes (diabetic peripheral neuropathy)
Nerve pain from shingles (postherpetic neuralgia)
Nerve pain from spinal cord injury
How Pregabalin (Lyrica) works
Pregabalin (Lyrica) is a type of medication called an antiepileptic or anticonvulsant. The exact way it works to treat nerve pain and seizures isn't fully understood. But it's thought to lower the level of certain chemicals in the brain. This might help relieve pain and prevent seizures.
Drug Facts
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What are the risks and warnings for Pregabalin (Lyrica)?
Pregabalin (Lyrica) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Allergic reactions and severe swelling
Risk factors: History of angioedema | Taking other medications that have a risk of angioedema (e.g., ACE inhibitors)
Some people have had an allergic reaction after taking pregabalin (Lyrica). These reactions can include skin redness, blisters, hives, rash, trouble breathing, or wheezing.
Rarely, a severe reaction called angioedema can also happen while taking pregabalin (Lyrica). This can cause swelling in your face, mouth (including your tongue, lips, or gums), or neck. Swelling of the tongue of neck can make it hard to breathe and can be life-threatening.
If you have an allergic reaction, swelling, or trouble breathing, stop taking pregabalin (Lyrica) and get medical help right away. Tell your prescriber that this happened so they can find a different medication for you to take.
Risk of suicidal thoughts and behavior
Risk factors: Taking anti-seizure medications | History of depression
Like other anti-seizure medications, pregabalin (Lyrica) can raise the risk of suicidal thoughts or behavior. This is rare, but the risk can appear as early as 1 week after starting the medication.
Be sure you and your loved ones watch for any signs of depression or unusual changes in mood or behavior. If this happens, tell your prescriber. If you start thinking about hurting yourself, call 911 right away.
Higher risk of side effects if you stop taking the medication too suddenly or too fast
Don't suddenly stop taking pregabalin (Lyrica) without first talking to your prescriber. Otherwise, you could have withdrawal symptoms that can be uncomfortable. This can include nausea, headache, trouble sleeping, anxiety, sweating, and diarrhea. It can sometimes include thoughts about hurting yourself. If you take the medication to control seizures, stopping it suddenly can cause more seizures to happen.
If you want to stop taking pregabalin (Lyrica), let your prescriber know. They'll help lower your dose slowly, usually over at least a week, before you can stop it completely. This helps lower the risk of withdrawal.
Slowed breathing
Risk factors: History of breathing problems | Taking pregabalin (Lyrica) with sedatives or other medications that calm the body
Pregabalin (Lyrica) might slow your breathing down. The risk is higher if you take it with other medications that have the same effect. This includes opioids and other medications that can slow your body down. Taking these medications with pregabalin (Lyrica) can make your breathing dangerously slow. This can be life-threatening.
Let your prescribers and pharmacist know about the medications you take. They can check if you're taking another medication that can slow down breathing and make it dangerous for you. Your care team might recommend adjustments to your medications to keep you safe.
If you or anyone around you notices that you have slow or shallow breathing or trouble breathing, get medical help right away.
Dizziness, sleepiness, and trouble concentrating
Pregabalin (Lyrica) can make you feel dizzy, sleepy, and tired. It can also make it hard for you to concentrate and think straight. These side effects generally happen when you start the medication and when you take higher doses. Some people can keep having these side effects until they stop taking the medication. Avoid doing things that need your focus, like driving or using machinery, until you know how pregabalin (Lyrica) affects you.
Swelling of the arms or legs
Risk factors: Taking certain diabetes medications | Heart failure
Pregabalin (Lyrica) can cause swelling of your arms or legs, which might be from fluid buildup in the body. The risk is higher if you take medications that can cause type this of swelling. One example is the diabetes medication pioglitazone (Actos). Tell your prescriber if you have heart failure since extra fluid in the body can make it worse.
If you have sudden weight gain or swelling in the arms, ankles, or feet, let your care team know. They can check to see what's going on.
Weight gain
Pregabalin (Lyrica) can cause weight gain. Sometimes, the weight gain is related to extra fluid built up in the body. But this might not be the case for everyone. The risk of weight gain is higher if you take a higher dose of the medication or if you take it for a long time.
Watch your weight while taking pregabalin (Lyrica) and tell your prescriber if you notice a lot of weight gain. Talk to your care team about ways to keep your weight healthy.
Lower platelet levels
In studies, some people taking pregabalin (Lyrica) had lower platelet levels. Platelets normally help your blood clot). When platelet levels are low, there's a possible risk of bleeding. But data from studies show that pregabalin (Lyrica) wasn't linked to a higher number of bleeding events.
To be safe, tell your prescriber if you notice blood in your urine or stool, easy bruising, or bleeding that takes longer to stop. They can check your platelet count through blood testing and make sure it's within a safe range.
Possible risk of muscle breakdown
Although rare, some people taking pregabalin (Lyrica) had higher creatine kinase levels. This can sometimes be a sign of muscle damage. Even rarer, a few people had a serious condition called rhabdomyolysis, which is when your muscles break down.
It's not clear how pregabalin (Lyrica) is related to these muscle problems. But tell your care team if you notice any unexplained muscle pain, tenderness, or weakness, particularly if you also have a fever. They can help figure out what's going on.
What are the side effects of Pregabalin (Lyrica)?
Common Side Effects
- Dizziness
- Drowsiness
- Headache
- Weight gain
Other Side Effects
- Weakness
- Tiredness
- Dry mouth
- Constipation
- Swelling in the arms or legs
- Blurry vision or other changes in vision
- Trouble paying attention or concentrating
- Problems with balancing
- Feeling very happy
Serious Side Effects
- Angioedema (severe swelling in the body): swelling in the face, lips, tongue, throat, hands, or feet; trouble breathing
- Severe allergic reaction: hives; trouble breathing; swelling of the face, lips, tongue, or throat
- Suicidal thoughts or behaviors
- Severe sleepiness
- Very slowed breathing
Source: DailyMed
More on Pregabalin (Lyrica) side effects
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
- Change in vision
- Muscle injury—unusual weakness or fatigue, muscle pain, dark yellow or brown urine, decrease in amount of urine
- Thoughts of suicide or self-harm, worsening mood, feelings of depression
- Trouble breathing
- Unusual bruising or bleeding
- Unusual changes in mood or behavior in children after use such as trouble concentrating, hostility, or restlessness
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Blurry vision
- Dizziness
- Drowsiness
- Dry mouth
- Swelling of the ankles, hands, or feet
- Weight gain
Pros and cons of Pregabalin (Lyrica)
Pros
Can take with other anti-seizure medications for partial-onset seizures in people as young as 1 month of age
Available in a capsule and liquid
Cons
Can cause dizziness and drowsiness
Can cause weight gain
Is a controlled substance, so there are some rules to follow to get it filled
Pharmacist tips for Pregabalin (Lyrica)
Take pregabalin (Lyrica) with or without food.
For the pregabalin (Lyrica) oral solution: Make sure to use the measuring device that the pharmacy gives you. This could be a dosing cup or oral syringe. Don't use household spoons because you could take or give the wrong amount of medication.
Pregabalin (Lyrica) can make you dizzy and sleepy. It can also make it hard for you to concentrate or see clearly. Don't drive or do anything that needs your full attention until you know how this medication affects you.
Don't drink alcohol while taking pregabalin (Lyrica). Mixing this medication with alcohol can make you feel more sleepy and dizzy. It can also make your breathing very slow, which can be dangerous.
Tell your prescribers and pharmacist about all the medications you take so they can check for dangerous interactions. It can be unsafe to take pregabalin (Lyrica) with opioids, benzodiazepines, muscle relaxants, and other sedatives. It can make you very sleepy, slow your reactions, or cause slow breathing. Your care team can adjust your medications to help keep you safe.
Pregabalin (Lyrica) can cause blurry vision and other vision changes. Tell your prescriber if you notice any changes in your vision while taking this medication.
Talk to your prescriber if you want to stop taking pregabalin (Lyrica). They can help come up with a plan to lower your dose slowly over time before you can stop. This helps lower your risk of unwanted side effects, like nausea, headache, trouble sleeping, and anxiety. If you take this medication for seizures, slowly lowering the dose can also lower your risk of more seizures.
If you miss a dose of pregabalin (Lyrica), take it as soon as you remember. But if it's almost time for your next dose, just skip the missed dose and take your next dose at your regular time. Don't double up doses to make up for a missed dose because this can raise your risk of side effects.
If you get pregnant while taking pregabalin (Lyrica), talk to your prescriber. It's recommended for you to join the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This safety program helps researchers learn more about the risks of taking this medication during pregnancy.
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Frequently asked questions about Pregabalin (Lyrica)
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Pregabalin (Lyrica) dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 473ml of 20mg/ml | 1 bottle | $1215.53 | $1215.53 |
Typical dosing for Pregabalin (Lyrica)
The dose will depend on why you're taking pregabalin (Lyrica). You'll usually start at a lower dose. Then after 1 week, your prescriber might adjust your dose if needed.
Adults
Nerve pain from diabetes: The typical starting dose is 50 mg by mouth three times a day.
Nerve pain from shingles: The typical starting dose is 50 mg by mouth three times a day, or 75 mg by mouth two times a day.
Nerve pain from spinal cord injury or fibromyalgia: The typical starting dose is 75 mg by mouth two times a day.
Partial-onset seizures (ages 17 years and older): The typical starting dose is 150 mg by mouth, split into 2 or 3 doses throughout the day.
Children ages 1 month and older
Partial-onset seizures: The prescriber will calculate the dose based on your child's body weight. The typical starting dose is 2.5 mg/kg or 3.5 mg/kg by mouth, split into 2 or 3 doses throughout the day.
Your dose might differ if you have kidney problems.
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How much does Pregabalin (Lyrica) cost?
What are alternatives to Pregabalin (Lyrica)?
Nerve pain from diabetes (diabetic peripheral neuropathy)
Nerve pain from shingles (postherpetic neuralgia)
Nerve pain from spinal cord injury
Nerve pain from shingles (postherpetic neuralgia) in adults
Partial (focal) seizures in people age 3 years and older
Nerve pain caused by shingles (postherpetic neuralgia)
What is the latest news about Pregabalin (Lyrica)?
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References
Best studies we foundBarad, M., et al. (2025). Neuropathic pain. Merck Manual Consumer Version.
Boomershine, C.S. (2010). Pregabalin for the management of fibromyalgia syndrome. Journal of Pain Research.
Centers for Disease Control and Prevention. (n.d.). Protect your child: Use the right tool to give the right dose.
Fernandez, J. (2024). Angioedema. Merck Manual Consumer Version.
Kiriakopoulos, E. (n.d.). Focal onset aware seizures (simple partial seizures). Epilepsy Foundation.
MedlinePlus. (2023). Creatine kinase.
Ryvlin, P., et al. (2008). Pregabalin for the management of partial epilepsy. Neuropsychiatric Disease and Treatment.
Viatris Specialty LLC. (2025). Lyrica- pregabalin capsule; Lyrica- pregabalin solution [package insert]. DailyMed.
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