The average list price of Keytruda (Pembrolizumab) is $11,337.36, but your out of pocket cost will likely be less if you have insurance. Vyleesi is covered by some Medicare and insurance plans. This drug is also a limited distribution drug, meaning it is not available at retail pharmacies. Refer to the Key Takeaways for additional information on Keytruda and check our savings tips for other ways to reduce your cost. A generic version of Keytruda is not yet available. With the Patient Assistance Program from Merck, you can receive your medication at no cost.