The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (27%)
- Constipation (22%)
- Nausea (21%)
- Sleepiness or tiredness (22%)
- Dizziness (14%)
- Indigestion (12%)
Less Common Side Effects
- Stomach pain
- Vomiting
- Diarrhea
- Gas
- Dry mouth
- Anxiety
- Nervousness
- Weakness
- Trouble sleeping
- Body swelling (edema)
- Itchiness
- Sweating
- Infection
Hydrocodone/Ibuprofen serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Slowed breathing
- Accidentally taking too much (overdose): not responding to sound or touch; slowed breathing; slow heartbeat; severe sleepiness; pale, blue, cold, or clammy skin
- Heart problem (heart attack, heart failure): trouble breathing, chest pain or tightness, tiredness, swelling in your body, sudden weight gain
- Stroke: blurred vision, trouble speaking or walking, weakness on one side of the body, droopy face
- Stomach or gut bleed: blood in your vomit, stool that looks like black coffee grounds, pain in your stomach that doesn't go away
- Opioid withdrawal: restlessness, muscle or joint pain, runny nose, yawning or sweating more than usual, chills, irritability, anxiety
- Serious allergic reaction or skin reaction: reddening or peeling of the skin, painful rash, fluid-filled blisters, fever, facial swelling, trouble breathing
- Seizures
Source: DailyMed
The following Hydrocodone/Ibuprofen side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Bloody stools
burning feeling in the chest or stomach
changes in facial skin color
difficulty with swallowing
fast or irregular breathing
frequent urge to urinate
irregular heartbeat
lightheadedness or dizziness
loss of bladder control
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
ringing or buzzing in the ears
tightness in the chest
trouble breathing
stomach pain
tenderness in the stomach
visual disturbances
yellow eyes or skin
Incidence not known
Agitation
confusion
darkening of the skin
difficulty swallowing
dizziness
fainting
loss of appetite
mental depression
overactive reflexes
poor coordination
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
restlessness
shivering
talking or acting with excitement you cannot control
trembling or shaking
twitching
unusual tiredness or weakness
vomiting
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Blurred vision
cold or clammy skin
confusion
difficulty hearing or ringing or buzzing in the ears
dizziness
general feeling of illness
headache
mood or mental changes
severe drowsiness
severe stomach pain
skin rash
slow heartbeat
stiff neck or back
swelling of the face, fingers, feet, or lower legs
vomiting
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
increased sweating
nervousness
pounding heartbeat
sleepiness
trouble in sleeping
Rare
Decreased appetite
decrease in sexual ability
headache
increased thirst
irritability
mood or mental changes
mouth ulcers
pain or burning in the throat
sensation of burning, warmth, heat, numbness, tightness, or tingling
slurred speech
stomach upset
thinking abnormalities
unexplained weight loss
unusual feeling of well-being
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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