glimepiride
Glimepiride (Amaryl) is a medication used to treat type 2 diabetes along with healthy diet and exercise. It's part of the medication class called sulfonylureas. This medication is taken by mouth, typically once daily with the first main meal. Some common side effects of glimepiride (Amaryl) include headaches and low blood sugar. Like other medications in its class, it can also cause weight gain. Glimepiride (Amaryl) is available as both a brand name (Amaryl) and generic tablet.
What is Glimepiride (Amaryl)?
What is Glimepiride (Amaryl) used for?
Type 2 diabetes in adults
How Glimepiride (Amaryl) works
Glimepiride (Amaryl) is a sulfonylurea. It works by attaching to certain pancreatic cells in your body that make insulin. When glimepiride (Amaryl) is attached, it tells your pancreas to release more insulin into the blood, which helps to lower blood sugar.
Drug Facts
More on Glimepiride (Amaryl) essentials
Get your GoodRx coupon
What are the side effects of Glimepiride (Amaryl)?
Common Side Effects
- Shakiness, anxiety, and other symptoms of low blood sugar levels (up to 20%)
- Headache (8%)
- Fever, cough, and other flu-like symptoms (5%)
- Nausea (5%)
- Dizziness (5%)
Other Side Effects
- Weight gain
Serious Side Effects
- Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling
- Low blood sugar: shakiness, fast heartbeat, sweating, dizziness, anxiety, confusion, feeling very hungry
Source: DailyMed
More on Glimepiride (Amaryl) side effects
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Difficulty with swallowing
dizziness
fast heartbeat
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
shortness of breath
skin rash
tightness in the chest
unusual tiredness or weakness
Incidence not known
Abdominal or stomach pain
agitation
back, leg, or stomach pains
bleeding gums
blistering, peeling, or loosening of the skin
bloating of abdomen
blood in the urine or stools
bloody, black, or tarry stools
chills
coma
confusion
cough or hoarseness
dark urine
decreased urine output
difficulty with breathing
fever with or without chills
fluid-filled skin blisters
general body swelling
general tiredness and weakness
headache
high fever
hostility
irritability
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
lethargy
light-colored stools
loss of appetite
lower back or side pain
muscle twitching
nosebleeds
painful or difficult urination
pale skin
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rapid weight gain
red, irritated eyes
red skin lesions, often with a purple center
seizures
sensitivity to the sun
skin thinness
sores, ulcers, or white spots on the lips or in the mouth
stupor
swelling of face, ankles, or hands
swollen or painful glands
unusual bleeding or bruising
upper right abdominal or stomach pain
yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Lack or loss of strength
Incidence not known
Redness or other discoloration of the skin
severe sunburn
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Glimepiride (Amaryl)
Pros
Available as a lower-cost generic medication
Only taken once a day
Taken by mouth
Cons
Need to take with the biggest meal of the day
More likely to cause weight gain compared to some other medications for diabetes
Might cause low blood sugar in breastfed babies and people ages 65 years and older
Pharmacist tips for Glimepiride (Amaryl)
Take glimepiride (Amaryl) at the same time every day with your first main meal. This helps to lower the risk of low blood sugar and to better absorb the medication into your body.
It's important to eat healthy and exercise regularly to keep your blood sugar under control. Make sure to work with your provider on a diet and exercise plan while taking glimepiride (Amaryl).
If possible, it's best to avoid alcohol when you're taking glimepiride (Amaryl). Drinking alcohol with this medication can cause dangerously low blood sugar. If you drink alcohol regularly and it's difficult for you to cut it out completely, ask your provider what's a safer amount to drink.
Glimepiride (Amaryl) can put you at risk of having low blood sugar. Your risk is higher if you're also using insulin. Make sure you eat consistent meals while taking glimepiride (Amaryl) to prevent your blood sugar from dropping too low. If you make any changes in your diet, talk with your provider because they might need to adjust the dose of your blood sugar medications.
Make sure to keep fast-acting sugars, such as glucose tablets or boxes of fruit juice, with you at all times. This is so that you can take them if your blood sugar level drops too low. Check your blood sugar if you feel confused, shaky, or have a fast heartbeat. Make sure you know how to treat low blood sugar (less than 70 mg/dL) and when you need to call 911.
Frequently asked questions about Glimepiride (Amaryl)
How to save using GoodRx
What are the risks and warnings for Glimepiride (Amaryl)?
Glimepiride (Amaryl) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Low blood sugar
Risk factors: Missing meals or having inconsistent meal times | Drinking alcohol | Intense or long periods of exercise | Taking medications that lower blood sugar | People ages 60 years or older | Kidney or liver problems
Glimepiride (Amaryl) can cause your blood sugar levels to drop to dangerously low levels. Symptoms of low blood sugar include feeling shaky, being nervous or anxious, fast heartbeat, sweating or body chills, confusion, and feeling very hungry. Make sure you and your family know how to treat low blood sugar and when they need to call 911. You might need to check your blood sugar more often to make sure it doesn't drop too much while taking this medication. It's best to keep emergency fast-acting sugars with you at all times, in case you need to bring your blood sugar back up to a safer range.
Serious allergic reactions
Risk factor: History of allergy to sulfa medications
Glimepiride (Amaryl) can sometimes cause serious allergic reactions, such as rash, peeling or blistering skin, swelling, trouble breathing, and dizziness. The risk is higher if you've had a history of allergy to sulfa medications, such as glipizide or sulfamethoxazole/trimethoprim (Bactrim). Before taking glimepiride (Amaryl), make sure to let your provider know about your medical history. If you experience an allergic reaction to glimepiride (Amaryl), stop the medication and get medical care right away.
Risk of low red blood cell count (hemolytic anemia)
Risk factor: People with low levels of glucose-6-phosphodiesterase (G6PD)
People who took medications similar to glimepiride (Amaryl) have experienced hemolytic anemia. If you've a certain genetic condition that raise your risk of this problem, your provider will most likely consider a different medication for you. Let your provider know if you experience symptoms of anemia, such as weakness, tiredness, or dizziness.
Possible risk of serious heart problems
A study of tolbutamide (a medication similar to glimepiride (Amaryl)) suggests that taking sulfonylureas might raise the risk of death due to heart problems. More research is needed in this area for glimepiride (Amaryl). Let your provider know right away if you experience any symptoms of heart attack (chest pain, sweating, nausea, or dizziness) or heart failure (trouble breathing, tiredness, swelling in your body, or sudden weight gain). Your provider might recommend that you go to the hospital and that you stop taking glimepiride (Amaryl).
Glimepiride (Amaryl) dosage forms
Typical dosing for Glimepiride (Amaryl)
The typical starting dose is 1 mg or 2 mg by mouth once daily with the first main meal of the day. Your provider will raise your dose every 1 to 2 weeks if you need to lower your blood sugar more. The maximum dose is 8 mg once daily.
Your dose might differ if you have kidney problems.
Interactions between Glimepiride (Amaryl) and other drugs
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aspirin
- Balofloxacin
- Besifloxacin
- Chloroquine
- Ciprofloxacin
- Desmopressin
- Disopyramide
- Dulaglutide
- Enoxacin
- Entacapone
- Fleroxacin
- Flumequine
- Gatifloxacin
- Gemifloxacin
- Hydroxychloroquine
- Isoniazid
- Lanreotide
- Levofloxacin
- Lixisenatide
- Lomefloxacin
- Metreleptin
- Miconazole
- Moxifloxacin
- Nadifloxacin
- Norfloxacin
- Octreotide
- Ofloxacin
- Pasireotide
- Pazufloxacin
- Pefloxacin
- Pioglitazone
- Porfimer
- Prulifloxacin
- Rufloxacin
- Sitagliptin
- Sparfloxacin
- Thioctic Acid
- Tosufloxacin
- Voriconazole
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Aminolevulinic Acid
- Atenolol
- Betaxolol
- Bisoprolol
- Bitter Melon
- Carteolol
- Carvedilol
- Celiprolol
- Colesevelam
- Esmolol
- Fenugreek
- Furazolidone
- Glucomannan
- Guar Gum
- Iproniazid
- Isocarboxazid
- Labetalol
- Levobunolol
- Linezolid
- Methylene Blue
- Metipranolol
- Metoprolol
- Moclobemide
- Nadolol
- Nebivolol
- Nialamide
- Oxprenolol
- Penbutolol
- Phenelzine
- Pindolol
- Practolol
- Procarbazine
- Propranolol
- Psyllium
- Rasagiline
- Safinamide
- Saxagliptin
- Selegiline
- Sotalol
- Timolol
- Tranylcypromine
How much does Glimepiride (Amaryl) cost?
Glimepiride (Amaryl) contraindications
People with a history of allergy to glimepiride or sulfa medications
What are alternatives to Glimepiride (Amaryl)?
What is the latest news about Glimepiride (Amaryl)?
Glimepiride (Amaryl) images
Get savings updates for Glimepiride (Amaryl)
Receive price alerts, news, and other messages from GoodRx about Glimepiride (Amaryl) and other healthcare topics and relevant savings offers.By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.
References
Best studies we foundAmerican Diabetes Association. (2012). Hypoglycemia? Low blood glucose? Low blood sugar? Clinical Diabetes.
American Diabetes Association. (n.d.). Understanding A1C: A1C looks back.
Aurobindo Pharma Limited. (2023). GLIMEPIRIDE tablet [package insert]. DailyMed.
Basit, A., et al. (2012). Glimepiride: Evidence-based facts, trends, and observations. Vascular Health and Risk Management.
Centers for Disease Control and Prevention. (2022). How to treat low blood sugar (hypoglycemia).
Costello, R. A., et al. (2023). Sulfonylureas. StatPearls.
Croke, L. (2020). Beers criteria for inappropriate medication use in older patients: An update from the AGS. American Family Physician.
ElSayed, N.A., et al. (2023). 9. Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes—2023. Diabetes Care.
MedlinePlus. (2023). Glucose-6-phosphate dehydrogenase deficiency.
National Center for Biotechnology Information. (n.d.). PubChem compound summary - glimepiride.
National Heart, Lung, and Blood Institute. (2022). Hemolytic anemia.
Compare other Diabetes Type 2 drugs
Browse medications
View AllResearch prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.