Is Your Medication Causing Dry Mouth?
Dry mouth isn’t just an annoyance, it can lead to serious dental issues if left untreated. Read on to see which medications are most likely to cause dry mouth.
tolterodine
Used for Overactive Bladder
Used for Overactive Bladder
Tolterodine (Detrol) is used to treat overactive bladder (OAB) in adults. It's an anticholinergic medication that helps with bladder control to lessen the need to go to the restroom suddenly or often. The immediate-release tablet (Detrol) is taken by mouth twice a day. There's also an extended-release capsule (Detrol LA) that's taken just once a day. Both formulations come in brand-name and generic-name versions. Tolterodine (Detrol) can commonly cause dry mouth. Other side effects can include headache and constipation.
What is Tolterodine (Detrol)?
What is Tolterodine (Detrol) used for?
- Overactive bladder (OAB)
How Tolterodine (Detrol) works
Tolterodine (Detrol) is an anticholinergic, or antimuscarinic. It blocks a chemical in your body called acetylcholine. This chemical normally attaches to certain proteins called muscarinic receptors, which are found in the bladder. This plays a role in bladder control.
When tolterodine (Detrol) blocks acetylcholine, it relaxes the bladder muscles. This helps reduce bladder spasms and the urge to urinate.
When does Tolterodine (Detrol) start working?Time passed since treatment started:
Drug facts
| Common Brands | Detrol, Detrol LA |
|---|---|
| Drug Class | Anticholinergic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Tolterodine (Detrol)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Less Common Side Effects
- Tiredness
- Dizziness
- Blurry vision
- Diarrhea
- Indigestion
- Flu-like symptoms
Tolterodine (Detrol) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction or angioedema (swelling): rash; hives; swelling in the face, lips, tongue, or throat; trouble breathing; wheezing
When do Tolterodine (Detrol) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Dry mouth
Constipation
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
The following Tolterodine (Detrol) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Abnormal vision, including difficulty with adjusting to distances
bloody or cloudy urine
difficult, burning, or painful urination
frequent urge to urinate
Less common
chills
general feeling of discomfort or illness
headache
joint pain
loss of appetite
muscle aches and pains
pain or tenderness around the eyes and cheekbones
shivering
shortness of breath or troubled breathing
stuffy or runny nose
sweating
tightness of the chest or wheezing
trouble with sleeping
vomiting
Incidence not known
Being forgetful
bloating or swelling of the face, arms, hands, ankles, lower legs, or feet
confusion about identity, place, and time
difficulty with swallowing
dizziness
fast, pounding, or irregular heartbeat or pulse
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
mood or mental changes
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rapid weight gain
seeing, hearing, or feeling things that are not there
skin rash
tingling of the hands or feet
unusual tiredness or weakness
unusual weight gain or loss
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Acid or sour stomach
belching
blurred vision
difficulty with moving
dizziness or lightheadedness
fear or nervousness
feeling of constant movement of self or surroundings
indigestion
sensation of spinning
sleepiness or unusual drowsiness
stomach discomfort
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$150.94
GoodRx discount
$26.15
Pros and cons of Tolterodine (Detrol)
Pros
- Works well to help lessen your urge to urinate
- Might cause less dry mouth than oxybutynin
- Also available in an extended-release version that's taken only once a day
Cons
- Can cause uncomfortable dry mouth and constipation
- Can make you feel sleepy or dizzy, which can raise your risk of falls
- Can't take if you have an allergy to another OAB medication called Toviaz (fesoterodine)
Pharmacist tips for Tolterodine (Detrol)
- You can take tolterodine (Detrol) with or without food. Food won't affect how well this medication works.
- For the immediate-release tablets: Take the medication twice a day at the same times each day. To help you remember, you can set up reminders on your phone. Or, you can make taking the medication a part of your daily routine, like when after you get up from bed in the morning and before you go to bed at night.
- For the extended-release capsules: Take the medication once a day around the same time each day. Swallow the capsule whole with water. Don't break, crush, or chew the capsule because this can change how safe the medication is for you. If you have trouble swallowing, ask your prescriber about your options.
- Take tolterodine (Detrol) every day, even if you don't feel any better right away. It can take a month or two of treatment before you see noticeable improvements. In the meantime, there are some things you can try to help. This includes pelvic muscle exercises, bladder retraining, and changes to your diet. Talk to your care team about ways to help manage your OAB.
- Tolterodine (Detrol) can sometimes make you drowsy or dizzy. It might also cause blurry vision. Don't drive or do anything that needs your full attention until you know how this medication affects you. Talk to your care team if these side effects bother you too much.
- It's common to have dry mouth while taking tolterodine (Detrol). Try chewing sugar-free gum or sucking on sugar-free hard candy. If it really bothers you, ask your prescriber about your options.
- Don't take tolterodine (Detrol) with other anticholinergics, like oxybutynin or Atrovent HFA (ipratropium). These medications work the same way and can cause similar side effects. Taking them together can make side effects like dry mouth, constipation, and dizziness worse. If you're not sure your medications are safe to take together, ask your prescriber or pharmacist.
Risks and warnings for Tolterodine (Detrol)
Tolterodine (Detrol) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious allergic reaction and swelling (angioedema)
Anaphylaxis or angioedema can happen after taking tolterodine (Detrol). These serious allergic reactions can occur the first time you take it or after any dose. They can be life-threatening, especially if your throat swells up and you have trouble breathing.
Watch for signs like rash; hives; swelling of your face, lips, or tongue; sudden dizziness; or trouble breathing. If this happens, call 911 right away. These can be signs of an allergic reaction that should get medical treatment quickly.
Dizziness and drowsiness
- Risk factors: Drinking alcohol | Taking other medications that make you less alert
Tolterodine (Detrol) can make you feel dizzy, drowsy, or less alert. This can happen particularly when you first start the medication. Don't drive or do anything that requires you to focus until you know how tolterodine (Detrol) affects you.
Caution use in people with narrow-angle glaucoma
Although rare, anticholinergic medications like tolterodine (Detrol) can raise the risk of a serious eye problem called narrow-angle glaucoma. You shouldn't take this medication if you have uncontrolled narrow-angle glaucoma. If you're not sure what type of glaucoma you have, ask your eye specialist. Talk to your prescriber to make sure tolterodine (Detrol) is safe for you.
Caution use in people with trouble urinating
Before starting tolterodine (Detrol), tell your prescriber if you have a blockage in your bladder that makes you have trouble urinating. This medication can make it harder to fully empty your bladder. It can make your bladder problem worse. Your prescriber can check if tolterodine (Detrol) is safe for you to take.
Caution use in people with problems causing gut blockage
Before starting tolterodine (Detrol), tell your prescriber if you have any problems that cause stomach or gut blockages. It might not be safe to take this medication. Tolterodine (Detrol) can slow your digestion, which can make your digestive problems worse. Your prescriber can make sure this medication is right for you.
Caution use in people with myasthenia gravis
If you have myasthenia gravis (MG), talk to your prescriber before taking tolterodine (Detrol). MG is a condition that affects your nerves and makes your muscles weak. The way tolterodine (Detrol) works can worsen your MG symptoms. Your prescriber can help you decide if this medication is right for you.
Caution use in people with certain heart rhythm problems
- Risk factors: QT prolongation | Taking a higher dose of tolterodine (Detrol) | Taking medications to control heartbeat
Studies suggest that higher doses of tolterodine (Detrol) might cause changes in heart rhythm. Tell your prescriber if you have a heart rhythm problem called QT prolongation. Also let them know if you take any medications that affect your heartbeat or can cause QT prolongation. Your prescriber can help make sure tolterodine (Detrol) is safe for you.
Tolterodine (Detrol) dosage
The average cost for 60 tablets of 2mg of Tolterodine (Detrol) is $27.03 with a free GoodRx coupon. This is 84.02% off the average retail price of $169.13.
Interactions between Tolterodine (Detrol) and other drugs
Tolterodine (Detrol) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Tolterodine (Detrol). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Bepridil
- Cisapride
- Dronedarone
- Mesoridazine
- Pimozide
- Piperaquine
- Potassium
- Saquinavir
- Sparfloxacin
- Terfenadine
- Thioridazine
- Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amiodarone
- Amisulpride
- Anagrelide
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Buprenorphine
- Bupropion
- Buserelin
- Ceritinib
- Clarithromycin
- Clofazimine
- Clozapine
- Crizotinib
- Dabrafenib
- Dasatinib
- Degarelix
- Delamanid
- Deslorelin
- Deutetrabenazine
- Domperidone
- Donepezil
- Efavirenz
- Encorafenib
- Entrectinib
- Escitalopram
- Fingolimod
- Fluconazole
- Fluoxetine
- Formoterol
- Foscarnet
- Fostemsavir
- Givosiran
- Glasdegib
- Glucagon
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gonadorelin
- Goserelin
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Inotuzumab Ozogamicin
- Ivabradine
- Ivosidenib
- Ketoconazole
- Lefamulin
- Lenvatinib
- Levofloxacin
- Lofexidine
- Macimorelin
- Methacholine
- Metronidazole
- Mirtazapine
- Moxifloxacin
- Nafarelin
- Nilotinib
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Pimavanserin
- Pitolisant
- Ponesimod
- Posaconazole
- Quetiapine
- Revefenacin
- Ribociclib
- Scopolamine
- Secretin Human
- Selpercatinib
- Sertraline
- Sevoflurane
- Siponimod
- Solifenacin
- Sotalol
- Sulpiride
- Sunitinib
- Tacrolimus
- Tiotropium
- Trazodone
- Triclabendazole
- Triptorelin
- Vandetanib
- Vemurafenib
- Vinflunine
- Voclosporin
- Zuclopenthixol
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
How much does Tolterodine (Detrol) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Tolterodine (Detrol) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Tolterodine (Detrol) will not be safe for you to take.
- Can't fully empty your bladder (urinary retention)
- Blockage in the digestive tract (gastric retention)
- Uncontrolled narrow-angle glaucoma
- Allergy to Toviaz (fesoterodine)
What are alternatives to Tolterodine (Detrol)?
There are a number of medications that your doctor can prescribe in place of Tolterodine (Detrol). Compare a few possible alternatives below.
News about Tolterodine (Detrol)
6 Medication Treatments for Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is a common condition in men over 50. A doctor may prescribe alpha blockers, anticholinergics, or other medications for BPH.
8 Types of Medications That Can Cause Constipation
Medications that are likely to cause constipation include opioids, antidepressants, antihistamines, and high blood pressure medications. Dietary changes and stool softeners can help bring some relief.
Myrbetriq for Urinary Incontinence: How It Works and Ways to Save
While pricey, Myrbetriq can help reduce urinary incontinence symptoms and improve bladder capacity. So is it worth the cost? Here’s our review of Myrbetriq.
What’s the Best Medication for Overactive Bladder?
Overactive bladder (OAB) medication can help improve your quality of life. Here’s everything to know about bladder control medications, including their costs and side effects.
Tolterodine (Detrol) images
