Key takeaways
Zyrtec-D (cetirizine/pseudoephedrine) and Advil Allergy and Congestion Relief (ibuprofen/phenylephrine/chlorpheniramine) are both over-the-counter medications used to treat allergy symptoms and congestion, but they have some key differences. Zyrtec-D combines an antihistamine (cetirizine) and a decongestant (pseudoephedrine) to relieve allergies and clear sinuses, while Advil Allergy and Congestion Relief includes an antihistamine (chlorpheniramine), a decongestant (phenylephrine), and an NSAID (ibuprofen) to also address pain and inflammation. Zyrtec-D is typically taken every 12 hours, whereas Advil Allergy and Congestion Relief needs to be taken every 4 hours. Zyrtec-D can cause trouble sleeping if taken too close to bedtime, while Advil Allergy and Congestion Relief can cause stomach bleeding and should be taken with food or milk. Additionally, Zyrtec-D is controlled in some states due to its pseudoephedrine content, requiring a photo ID for purchase, whereas Advil Allergy and Congestion Relief is not a controlled medication. Both medications should be used with caution if you have certain health conditions. Advil Allergy and Congestion Relief may need to be avoided in people with heart or stomach issues.
