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Zymaxid vs. Levaquin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Gatifloxacin (Zymaxid) and Levofloxacin (Levaquin) are both fluoroquinolone antibiotics, but they are used differently. Gatifloxacin is an eye drop used to treat bacterial conjunctivitis (pink eye) and is suitable for people aged 1 year and older. It is applied multiple times a day for about a week. In contrast, Levofloxacin is taken orally and treats a variety of serious bacterial infections, including pneumonia and urinary tract infections. It is usually taken once daily. Levofloxacin has more serious potential side effects, such as tendon rupture and nerve damage, and is generally reserved for more severe infections or when other antibiotics are not suitable. Gatifloxacin, being an eye drop, has fewer systemic side effects but can cause eye irritation. Both medications are available in generic forms.

Gatifloxacin

(Zymaxid)

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Levofloxacin

 

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Summary for Zymaxid

Prescription only

Gatifloxacin (Zymaxid) is a fluoroquinolone antibiotic eye drop. It works well to treat pink eye caused by certain types of bacteria, but it doesn't treat pink eye caused by viruses. Gatifloxacin (Zymaxid) is approved for people ages 1 year and older. It's placed in the eye multiple times a day. Typically, treatment lasts about a week. Some of the more common side effects of gatifloxacin (Zymaxid) include eye irritation and changes in taste in your mouth.

Indications for Zymaxid

Pros and Cons for Zymaxid

Pros

  • Causes fewer serious side effects than oral antibiotics
  • Can be given to children age 1 year or older
  • Available as a lower-cost, generic form

Cons

  • Has to be used multiple times a day
  • Can cause temporary eye irritation after applying
  • Won't be able to treat pink eye caused by virus(es)

Common Side Effects for Zymaxid

  • Worsening of eye infection
  • Eye irritation
  • Eye pain
  • Changes the taste in your mouth

Warnings for Zymaxid

  • Allergic reactions
  • New infection

Summary for Levaquin

Prescription only

Levofloxacin is a fluoroquinolone antibiotic. It can treat many types of bacterial infections, including pneumonia and urinary tract infections (UTIs). But because levofloxacin can cause serious side effects, such as tendon rupture and nerve damage, it's usually only prescribed for more serious infections or when safer options aren't available. Levofloxacin is taken by mouth, typically once daily. Some of the more common side effects of this medication include nausea, headache, and diarrhea. Levofloxacin is generic only, brand-name Levaquin is no longer available.

Indications for Levaquin

Adults only

Adults and children

Pros and Cons for Levaquin

Pros

  • Usually taken once per day
  • Available as tablets, oral liquid, and injection
  • Available as a lower-cost generic

Cons

  • Has many potentially serious side effects and risks (e.g, nerve issues, irregular heartbeat)
  • Might cause muscle, bone, and joint problems in children
  • Interacts with some antacids and multivitamins

Common Side Effects for Levaquin

  • Nausea (7%)
  • Headache (6%)
  • Diarrhea (5%)
  • Trouble sleeping (4%)

Warnings for Levaquin

  • Tendon inflammation and rupture
  • Effects on the brain, nerves, and mental health
  • Worsening of myasthenia gravis
  • Severe allergic and skin reactions
  • Liver damage
  • Severe blood vessel (aorta) damage
  • Diarrhea from Clostridioides difficile infection
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Muscle, bone, and joint problems in children
  • Sun and light sensitivity

Prices with our coupons for Zymaxid vs. Levaquin

Price Card Drug Icon
Gatifloxacin1 eye dropper / 2.5ml of 0.5%
$35.54$117.17
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Levofloxacin10 tablets / 500mg
$10.25$17.05
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