Key takeaways
Zyban (bupropion) and Chantix (varenicline) are both prescription medications used to help you quit smoking, but they have some key differences. Zyban is an atypical antidepressant that increases norepinephrine and dopamine levels in your brain to help with mood and withdrawal symptoms. Chantix, on the other hand, is a partial nicotine receptor agonist that works in the same part of your brain as nicotine to reduce cravings and withdrawal symptoms. Zyban is typically taken twice daily for 7 to 12 weeks. Chantix, on the other hand, follows a specific dosing schedule and is usually taken for 12 weeks, with the possibility of an additional 12 weeks. Zyban can cause mood changes, seizures, and high blood pressure, while Chantix can cause nausea, vivid dreams, and mental health changes. Both medications are available in generic forms, making them more affordable options.
