Key takeaways
Bupropion (Wellbutrin SR, Wellbutrin XL, Forfivo XL) and phentermine (Adipex-P) are both oral medications, but they belong to different drug classes and treat different conditions. Bupropion is an atypical antidepressant used to treat depression and seasonal affective disorder (SAD), while phentermine is a sympathomimetic used for short-term weight management in adults with a high body mass index (BMI). Bupropion is available in various formulations, including immediate-release, sustained-release (Wellbutrin SR), and extended-release (Wellbutrin XL, Forfivo XL) tablets, and is available as a generic. Phentermine is available as tablets and capsules and is also available as a generic. Bupropion can cause side effects like headache, dry mouth, and trouble sleeping, and it carries a risk of seizures, especially if you have a history of seizures. Phentermine can cause side effects like dry mouth, headache, and high blood pressure, and it has a risk of misuse and dependence because it is a controlled substance. Additionally, bupropion is not recommended for people with a history of seizures or eating disorders, while phentermine should be avoided if you have heart problems or uncontrolled high blood pressure.
