Key takeaways
Bupropion (Wellbutrin) and trazodone are both atypical antidepressants, but they have some key differences. Bupropion is used to treat depression and seasonal affective disorder, while trazodone is primarily used for depression and sometimes off-label for insomnia. Bupropion works by boosting norepinephrine and dopamine levels in the brain, whereas trazodone affects serotonin levels. Bupropion is available in both generic and brand forms, while the brand name for trazodone, Desyrel, has been discontinued, leaving only the generic version. Bupropion is less likely to cause weight gain and sexual side effects compared to other antidepressants, but it can increase the risk of seizures. It is not recommended for people with a history of seizures or eating disorders. In contrast, trazodone is known for causing sleepiness and dizziness and may lead to serious heart rhythm problems and low blood pressure. Both medications can cause withdrawal symptoms if stopped abruptly and may worsen depression or cause suicidal thoughts, particularly in younger individuals.
