Key takeaways
Bupropion (Wellbutrin) and escitalopram (Lexapro) are both medications used to treat depression, but they belong to different drug classes and work in different ways. Bupropion is an atypical antidepressant that boosts norepinephrine and dopamine levels in the brain, while escitalopram is a selective serotonin reuptake inhibitor (SSRI) that raises serotonin levels. Bupropion is also used to treat seasonal affective disorder and is available in both short-acting and long-acting forms, whereas escitalopram is also used for generalized anxiety disorder (GAD) and is available as a tablet and liquid. Bupropion has fewer sexual side effects and is less likely to cause weight gain compared to other antidepressants, but it can increase the risk of seizures, especially in people with a history of seizures. For depression, bupropion can be used alone or in combination with other antidepressants. On the other hand, escitalopram is considered a first-choice medication for depression and anxiety but can cause sexual problems and has a risk of withdrawal symptoms if stopped suddenly.
