Key takeaways
Bupropion (Wellbutrin) and citalopram (Celexa) are both medications used to treat depression, but they belong to different drug classes and work in different ways. Bupropion is an atypical antidepressant that boosts norepinephrine and dopamine levels in the brain, while citalopram is a selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels. Bupropion is available in short-acting, sustained-release, and extended-release tablets, whereas citalopram comes as a tablet, liquid, and capsule. Bupropion is less likely to cause weight gain and sexual side effects compared to other antidepressants, but it can increase the risk of seizures, especially in people with a history of seizures. Citalopram, on the other hand, has a low risk of weight gain but can cause serious heart rhythm problems (QT prolongation) and serotonin syndrome if taken with other medications that affect serotonin levels. Both medications can take several weeks to show their full effects and should not be stopped suddenly to avoid withdrawal symptoms.
