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Vascepa vs. Lovaza

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Icosapent ethyl (Vascepa) and omega-3-acid ethyl esters (Lovaza) are both used to lower triglyceride levels in adults, but they have some key differences. Vascepa contains only one type of omega-3 fatty acid, while Lovaza contains two types: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Vascepa is typically taken twice a day, whereas Lovaza can be taken once or twice a day. Vascepa is also used to lower the risk of heart problems in people taking statins who have high triglycerides and other risk factors, while Lovaza is mainly used for very high triglyceride levels. Common side effects of Vascepa include muscle and bone pain, while Lovaza often causes burping and changes in taste. Both medications are available as lower-cost generics and should be taken with food.

Icosapent ethyl

(Vascepa)

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Omega-3 acids

(Lovaza)

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Summary for Vascepa

Prescription only

Icosapent ethyl (Vascepa) contains omega-3 fatty acids from fish oil and is used to lower triglyceride (TG) levels in adults. When taken together with a statin, icosapent ethyl (Vascepa) can help protect the heart of certain people who are at high risk of heart disease. The medication is taken by mouth twice daily. Icosapent ethyl (Vascepa) is available as a brand-name capsule and also has generic alternatives. The most common side effects include muscle and bone pain, swelling in the arms and legs, and constipation.

Indications for Vascepa

  • Lower the risk of heart problems in adults also taking statins who have high triglyceride levels, and have heart disease or diabetes with at least 2 risk factors for heart disease
  • Lower triglyceride levels in adults with very high triglycerides levels when taken together with a healthy diet

Pros and Cons for Vascepa

Pros

  • Has been shown to lower the risk for heart problems in people with heart disease or diabetes with other risk factors
  • Good choice for people with very high triglyceride levels
  • Safe for use in people age 65 and older
  • Available as a lower-cost generic medication

Cons

  • Might raise your risk of bleeding
  • Needs to be taken twice a day with food
  • Might need to take many capsules per day, depending on your dose
  • Risk of allergic reaction if you're allergic to fish or shellfish

Common Side Effects for Vascepa

  • Muscle, bone, and joint pain
  • Swelling in arms, legs, hands, or feet
  • Constipation
  • Gout
  • Irregular heart rhythm
  • Pain in mouth and throat

Warnings for Vascepa

  • Heart rhythm problems (atrial fibrillation or atrial flutter)
  • Allergic reactions in people who have fish allergies
  • Bleeding

Summary for Lovaza

Prescription only

Omega-3-acid ethyl esters (Lovaza) is made up of two different omega-3 fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This medication is used to lower triglycerides (TG) levels in adults. It works best when you're also eating a low-cholesterol diet and engaging in regular exercise. Omega-3 acids (Lovaza) is taken by mouth once or twice per day with food. Some side effects include burping, upset stomach, and changes in your sense of taste.

Indications for Lovaza

  • Add-on to diet for the treatment of high triglycerides (TG) in adults with TG levels greater than 500 mg/dL

Pros and Cons for Lovaza

Pros

Cons

  • Approved for adults only
  • Might not be appropriate for people with fish or shellfish allergies
  • Can cause burping and changes in taste as side effects
  • Capsule might be hard to swallow for some people

Common Side Effects for Lovaza

  • Burping (4%)
  • Changes in taste (4%)
  • Upset stomach (3%)

Warnings for Lovaza

  • Fish allergy
  • Heart rhythm problems (atrial fibrillation or atrial flutter)
  • Risk of liver irritation

Prices with our coupons for Vascepa vs. Lovaza

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Vascepa120 capsules / 1g
$98.40$406.22
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Omega-3-Acid Ethyl Esters120 capsules / 1g
$33.40$71.70
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