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Twyneo vs. Epiduo

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Twyneo

(tretinoin / benzoyl peroxide)

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Epiduo

(adapalene / benzoyl peroxide)

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Summary for Twyneo

Prescription only

Twyneo (tretinoin / benzoyl peroxide) is a prescription medication used to treat acne in adults and children 9 years and older. It’s the first FDA-approved treatment to safely combine two common acne-fighting ingredients: tretinoin (a retinoid) and benzoyl peroxide (an antiseptic). The medication comes as a cream that you apply once a day to the affected areas. Common side effects include redness, peeling, and dry skin.

Indications for Twyneo

Pros and Cons for Twyneo

Pros

  • Combines two medications into one product for convenience
  • Can be used by adults and children ages 9 and up
  • Only needs to be applied once a day

Cons

  • For some people, acne improvement can take weeks to months
  • Can bleach hair and fabrics
  • Might cause your skin to become more sensitive to the sun

Common Side Effects for Twyneo

  • Stinging, burning, or pain (11%)
  • Dryness (5%)
  • Peeling (4%)
  • Redness (4%)

Warnings for Twyneo

  • Serious allergic reactions
  • Skin Irritation
  • Sun sensitivity

Summary for Epiduo

Prescription only

Epiduo (adapalene / benzoyl peroxide) is a topical gel that contains two active ingredients: adapalene (a retinoid) and benzoyl peroxide (an antiseptic). It's FDA approved to treat acne (pimples) in adults and children. The gel is typically applied to the skin once a day. Side effects aren't common, but can include dry skin, skin irritation, and skin burning. The medication is available as a generic and under two brand names: Epiduo and Epiduo Forte.

Indications for Epiduo

  • Acne in
    • People 9 years and older - Epiduo
    • People 12 years and older - Epiduo Forte

Pros and Cons for Epiduo

Pros

  • Combination of two medications in a single product
  • Only needs to be applied once a day
  • Easy to apply
  • Available as a lower-cost generic

Cons

  • Can make your skin more sensitive to the sunlight
  • Can bleach clothing and bed sheets
  • Can make skin dry or irritated
  • Your skin might look worse before it starts looking better

Common Side Effects for Epiduo

Epiduo:

  • Dry skin (7%)
  • Rash (3%)

Epiduo Forte:

  • Skin irritation (4%)

Warnings for Epiduo

  • Sunburn
  • Skin irritation

Prices with our coupons for Twyneo vs. Epiduo

Price Card Drug Icon
Twyneo1 pump / 30g of 0.1%/3%
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Price Card Drug Icon
Adapalene/Benzoyl Peroxide1 tube / 45g of 0.1%/2.5%
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