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Triumeq vs. Truvada

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Triumeq (abacavir/dolutegravir/lamivudine) and Truvada (emtricitabine/tenofovir disoproxil fumarate) are both used to treat HIV, but they have some key differences. Triumeq is a single-tablet regimen that combines three medications, while Truvada combines two medications and must be taken with another HIV medication for complete treatment. Triumeq requires a genetic test before starting to check for a risk of serious allergic reactions, whereas Truvada does not. Truvada is also approved for HIV PrEP (pre-exposure prophylaxis) to prevent HIV infection, while Triumeq is not. Triumeq can cause serious liver problems and requires careful monitoring, especially if you have hepatitis B, while Truvada is more likely to cause bone problems and kidney issues. Additionally, Truvada is available as a lower-cost generic, making it more accessible. Both medications are taken once daily and require regular blood tests to monitor for side effects and effectiveness.

Summary for Triumeq

Prescription only

Triumeq is a single-tablet regimen used to treat human immunodeficiency virus (HIV) infections. It contains 3 antiretrovirals (ARVs): abacavir, dolutegravir, and lamivudine. Triumeq is available as either a tablet or a dissolvable tablet for oral suspension (Triumeq PD), but the two are not the same. Before starting treatment, your provider will require you to get a genetic test to see if you're at risk for developing a serious allergic reaction to this medication.

Indications for Triumeq

  • Treatment of HIV infection (in people who weigh at least 13 pounds)

Pros and Cons for Triumeq

Pros

  • Only taken once a day for complete HIV treatment
  • Combines three medications into one pill for convenience
  • Can be taken with or without food
  • Available for adults and children at or over 22 lbs

Cons

  • Dose can't be adjusted so it's not recommended for people with kidney or liver problems
  • Not safe to use in severe liver problems
  • Requires a genetic test before starting
  • Interacts with a lot of medications such as St. John’s wort and oxcarbazepine (Trileptal)

Common Side Effects for Triumeq

  • Higher lipase levels (suggesting irritated pancreas) (up to 11%)
  • Higher blood sugar levels (up to 9%)
  • Higher creatine kinase levels in the blood (suggesting muscle damage) (up to 7%)
  • Higher fat levels in the blood (up to 6%)
  • Higher white blood cell count (up to 4%)
  • Abnormal liver labs (up to 3%)
  • Trouble sleeping (3%)
  • Headache (2%)
  • Feeling tired (2%)

Please note: The side effects listed above are from clinical trials with Tivicay (dolutegravir) and Epzicom (abacavir / lamivudine), which are all active ingredients in Triumeq and Triumeq PD

Warnings for Triumeq

  • Serious allergic reaction
  • Worsening of hepatitis B virus (HBV) infection
  • Liver problems
  • Overactive immune system
  • Interaction with other medications

Summary for Truvada

Prescription only

Truvada, also known as TDF/FTC, is a combination medication that contains the antiretrovirals emtricitabine and tenofovir disoproxil fumarate. Truvada is used as part of an antiretroviral (ARV) regimen to treat HIV (human immunodeficiency virus) infections in adults and children. It's also preferred for HIV PrEP (pre-exposure prophylaxis or prevention). This medication works against HIV by stopping the virus from making copies of itself and spreading. Truvada tablets are taken by mouth once daily. Side effects when it's used for treating HIV include nausea, diarrhea, and dizziness. And Truvada side effects when used for PrEP include headache and belly pain.

Indications for Truvada

Pros and Cons for Truvada

Pros

  • Only taken once a day
  • Available as a lower-cost generic medication
  • Is a complete regimen for HIV PrEP
  • 99% effective for preventing HIV infection from sex when used as prescribed for PrEP

Cons

  • Requires regular blood work and lab tests to make sure your liver and kidneys are healthy
  • Not a complete treatment for HIV (must take one other medication with it)
  • Can worsen hepatitis B if you stop taking the medication all of a sudden
  • More likely to cause bone problems than similar medications

Common Side Effects for Truvada

HIV treatment Note: Side effects for HIV treatment were reported by people taking Truvada with efavirenz (Sustiva).

  • Higher cholesterol levels (22%)
  • Higher creatine kinase levels (9%)
  • Feeling tired (9%)
  • Depression (9%)
  • Nausea (9%)
  • Diarrhea (9%)
  • Dizziness (8%)
  • Upper respiratory infections (8%)
  • Sinus infection (congestion; 8%)
  • Rash (7%)
  • Headache (6%)

HIV PrEP (prevention)

  • Headache (7%)
  • Belly pain (4%)
  • Lower weight (3%)

Warnings for Truvada

  • Worsening of hepatitis B infection
  • PrEP only for people who test negative for HIV
  • Kidney problems
  • Overactive immune system
  • Bone problems
  • Liver problems and lactic acidosis
  • Interaction with other medications

Prices with our coupons for Triumeq vs. Truvada

Price Card Drug Icon
Triumeq30 tablets / 600mg/50mg/300mg
$3,906.39$5,011.89
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Emtricitabine/Tenofovir30 tablets / 200mg/300mg
$27.53$2,099.99
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