Key takeaways
Triumeq (abacavir/dolutegravir/lamivudine) and Juluca (dolutegravir/rilpivirine) are both HIV antiretroviral (ARV) medications, but they have some key differences. Triumeq is a three-drug combination that includes abacavir, dolutegravir, and lamivudine, and is used for treating HIV in people who weigh at least 13 pounds. It requires a genetic test before starting to check for a risk of serious allergic reactions. Juluca, on the other hand, is a two-drug combination of dolutegravir and rilpivirine, and is only for people who are already well-controlled on their current HIV regimen and want to switch. Unlike Triumeq, Juluca must be taken with a meal and cannot be used with proton pump inhibitors like omeprazole. Both medications can cause serious allergic reactions and liver problems, but Juluca also has a risk of mood changes and depression. Triumeq is available as both a regular tablet and dissolvable tablet for children, while Juluca is only available as a regular tablet.
