Key takeaways
Tresiba (insulin degludec) and Humalog (insulin lispro) are both insulins used to manage diabetes, but they have different characteristics and uses. Tresiba is a long-acting insulin that helps control blood sugar levels over a full day and can be taken at any time of the day. In contrast, Humalog is a fast-acting insulin that works quickly to lower blood sugar levels after meals and is typically taken multiple times a day. Tresiba is only available as a brand-name medication and only in pen form, while Humalog is available in both vials and prefilled pens, including different versions like the KwikPen and has lower-cost follow-on or unbranded option available. Tresiba is suitable for children as young as 1 year old, whereas Humalog can be used in children as young as 3 years old. Both medications can cause low blood sugar and weight gain, but Tresiba is taken once daily, while Humalog requires more frequent dosing. Additionally, Tresiba can be stored at room temperature for up to 56 days, whereas Humalog is good for 28 days after opening.
