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Toprol XL vs. Bystolic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Metoprolol succinate (Toprol XL) and nebivolol (Bystolic) are both beta blockers, but they have some key differences. Metoprolol succinate is used to treat high blood pressure, chest pain, and to lower the risk of hospitalization and death in people with heart failure. In contrast, nebivolol is primarily used to treat high blood pressure and is not a first-choice medication for this condition. Metoprolol succinate is available in both brand (Toprol XL) and generic forms, while nebivolol is available as both brand (Bystolic) and generic. Metoprolol succinate needs to be taken with food, whereas nebivolol can be taken with or without food. Additionally, nebivolol is less likely to cause erectile dysfunction and weight gain compared to other beta blockers, including metoprolol succinate. Both medications can cause dizziness and tiredness, and you should not stop taking either suddenly without consulting your healthcare provider.

Metoprolol succinate

(Toprol XL)

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Nebivolol

(Bystolic)

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Summary for Toprol XL

Prescription only

Metoprolol succinate (Toprol XL) is used to treat hypertension and to control chronic (long-term) chest pain. It's also used to lower the risk for hospitalization and death in people with heart failure. Metoprolol succinate (Toprol XL) is the extended-release version of metoprolol tartrate (Lopressor), but keep in mind the two versions don't treat the exact same conditions. And because metoprolol succinate (Toprol XL) is longer-acting, it's taken by mouth typically taken just once daily. Some common side effects of metoprolol succinate (Toprol XL) include tiredness or dizziness.

Indications for Toprol XL

  • High blood pressure
  • Chest pain (angina)
  • Lower the risk of hospitalization and death in heart failure

Pros and Cons for Toprol XL

Pros

  • A first-choice option to prevent chest pains (angina)
  • A first-choice option for heart failure
  • Only needs to be taken once a day
  • Available as capsules (Kapspargo) that can be opened and sprinkled on soft foods, good for people who've trouble swallowing pills

Cons

Common Side Effects for Toprol XL

  • Tiredness
  • Dizziness
  • Depression
  • Diarrhea
  • Trouble catching your breath
  • Drop in heart rate
  • Rash

Please note: The side effects above occurred in 2% or more of people taking metoprolol succinate (Toprol XL).

Warnings for Toprol XL

  • Heart problems after suddenly stopping the medication
  • Worsened symptoms of heart failure
  • Risk of difficulty breathing
  • Rise in blood pressure in people with pheochromocytoma
  • Greater risk during surgery
  • Hiding symptoms of low blood sugar
  • Masked symptoms of overactive thyroid

Summary for Bystolic

Prescription only

Nebivolol (Bystolic) is a beta blocker. It's used to treat high blood pressure in adults, but it's not a first-choice medication for this condition. The typical dose is to take one tablet by mouth daily. Some of the more common side effects of nebivolol (Bystolic) include dizziness and tiredness. Don't drink alcohol while taking this medication because doing so can worsen dizziness. Nebivolol (Bystolic) is less likely to cause erectile dysfunction and weight gain compared to other beta blockers. It's available as both brand name Bystolic and generic nebivolol.

Indications for Bystolic

Pros and Cons for Bystolic

Pros

  • Only need to take it once a day
  • Can be taken with or without food
  • Less likely to cause certain side effects, like erectile dysfunction, compared to other beta blockers
  • Available as a lower-cost generic

Cons

  • Not a first-choice medication to lower blood pressure
  • Can hide symptoms of low blood sugar if you have diabetes
  • Not recommended if you're breastfeeding
  • Can't suddenly stop the medication because it can raise your risk of chest pain or heart attack

Common Side Effects for Bystolic

  • Headache (6-9%)
  • Tiredness (2-5%)
  • Dizziness (2-4%)
  • Diarrhea (2-3%)
  • Nausea (1-3%)

Warnings for Bystolic

  • Heart attack or irregular heart rhythm
  • Risk of difficulty breathing
  • Hiding symptoms of low blood sugar
  • Hiding symptoms of high thyroid hormone
  • Risk during surgery
  • Severe allergic reactions

Prices with our coupons for Toprol XL vs. Bystolic

Price Card Drug Icon
Metoprolol ER90 tablets / 25mg
$15.75$101.53
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Nebivolol30 tablets / 5mg
$12.92$73.68
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