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Tegretol vs. Trileptal

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Carbamazepine (Tegretol) and oxcarbazepine (Trileptal) are both antiepileptic medications used to treat seizures, but they have some key differences. Carbamazepine is used for a wider range of conditions, including partial-onset seizures, generalized tonic-clonic seizures, mixed seizure patterns, trigeminal neuralgia, and bipolar I disorder (Equetro brand only). In contrast, oxcarbazepine is primarily used for partial-onset seizures. Carbamazepine comes in various forms, such as immediate-release tablets, chewable tablets, oral suspensions, and extended-release tablets, while oxcarbazepine is available as immediate-release tablets, oral suspensions, and extended-release tablets. Both medications can cause dizziness and nausea, as well as a risk of causing serious side effects like low blood cell counts. Additionally, carbamazepine is known to cause weight gain and sexual problems, whereas oxcarbazepine's side effects include headaches and upper respiratory tract infections. Neither medication is recommended during pregnancy, but oxcarbazepine's safety is less clear due to limited studies.

Carbamazepine

(Tegretol)

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Oxcarbazepine

(Trileptal)

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Summary for Tegretol

Prescription only

Carbamazepine (Tegretol) is an antiseizure medication used to treat different kinds of seizures. It can also help with trigeminal neuralgia, a type of facial nerve pain. Brand name Equetro is the only formulation that's approved to treat bipolar I disorder. Carbamazepine (Tegretol) available as pills and a liquid. Depending on formulation you take and what medical condition you have, carbamazepine (Tegretol) is taken by mouth 1 to 4 times per day. Common side effects include sleepiness, dizziness, and stomach upset.

Indications for Tegretol

Pros and Cons for Tegretol

Pros

  • Works well for different types of seizures and trigeminal neuralgia (facial nerve pain)
  • Helps stabilize mood in people with bipolar disorder (Equetro brand only)
  • Available as a lower-cost generic
  • Comes in many dosage forms (e.g., chewable tablets, oral pills, liquid form) for people who have difficulty swallowing pills

Cons

  • Might need to take the immediate-release form of the medication up to 4 times a day
  • Can cause a lot of side effects
  • Might require routine blood testing while taking the medication to see how it's affecting your body
  • Can make hormonal birth control not work as well

Common Side Effects for Tegretol

  • Dizziness (44%)
  • Sleepiness (32%)
  • Nausea (29%)
  • Vomiting (18%)
  • Difficulty walking or keeping balance (15%)
  • Constipation (10%)
  • Itching (8%)
  • Dry mouth (8%)
  • Weakness (8%)
  • Rash (7%)
  • Blurry vision (6%)
  • Speech problems (6%)

Warnings for Tegretol

  • Severe skin reactions
  • Low blood cell counts
  • Severe allergic reactions
  • Suicidal thoughts or behavior
  • Harm to unborn babies
  • Withdrawal
  • Difficulty with speech, concentration, and movement
  • Liver problems
  • Low sodium levels
  • High eye pressure
  • Heart block (heart rhythm problems)

Summary for Trileptal

Prescription only

Oxcarbazepine (Trileptal) is used to treat partial-onset seizures (also called focal aware seizures). This antiepileptic is for people 2 years of age and older. It helps calm the brain to keep seizures from happening. Oxcarbazepine (Trileptal) comes as immediate-release tablets and an oral suspension. You take it by mouth twice a day. Some common side effects include dizziness, nausea, and headaches. Immediate-release oxcarbazepine comes in both brand-name and generic versions. You can take it by itself or with other anti-seizure medications.

Indications for Trileptal

Pros and Cons for Trileptal

Pros

  • Okay for children as young as 2 years old with partial-onset seizures to take
  • Available as an oral liquid for people who have trouble swallowing the tablets
  • Dose can be adjusted based on response to the medication

Cons

  • Can make it hard to focus and react quickly
  • Can cause serious skin reactions
  • Interacts with many medications, including some antidepressants and other seizure medications

Common Side Effects for Trileptal

  • Dizziness
  • Sleepiness
  • Tiredness
  • Nausea
  • Vomiting
  • Headache
  • Trouble walking
  • Double vision
  • Other changes in vision
  • Shaky eye movements (nystagmus)

Note: Side effects were reported by people who took oxcarbazepine (Trileptal) either by itself or with other seizure medications.

Warnings for Trileptal

  • Low sodium levels
  • Severe allergic reaction
  • Serious skin reactions
  • Risk of suicidal thoughts and behavior
  • Trouble with concentration, speech, and movement
  • Higher risk of having new seizures
  • Withdrawal seizures

Prices with our coupons for Tegretol vs. Trileptal

Price Card Drug Icon
Carbamazepine180 tablets / 200mg
$41.68$115.58
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Oxcarbazepine60 tablets / 300mg
$9.00$9.00
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