Key takeaways
Tazarotene (Tazorac) and tretinoin (Retin-A) are both topical retinoids used to treat acne. They work by promoting the growth of new skin cells and unclogging pores. Tazarotene is also FDA-approved for treating plaque psoriasis, while tretinoin is not. And both medications are often used off-label for fine wrinkles and sun damage. Tazarotene may be more effective that tretinoin, especially for severe symptoms. but it may also come with more side effects. Both medications are applied once daily, typically in the evening. They have similar side effects, such as skin irritation and increased sensitivity to sunlight.
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