Key takeaways
Tazarotene (Tazorac) and tretinoin (Retin-A) are both topical retinoids used to treat acne. They work by promoting the growth of new skin cells and unclogging pores. However, tazarotene is also FDA-approved for treating plaque psoriasis, while tretinoin is not. Tazarotene is available as a cream and gel, and tretinoin is available as a cream or gel as well. Both medications are applied once daily, but tazarotene is typically used in the evening, whereas tretinoin is applied before bedtime. Tazarotene is not safe during pregnancy, while tretinoin's safety during pregnancy is not well-studied, and it is generally not recommended. Common side effects for both include skin irritation and increased sensitivity to sunlight, but tazarotene can also cause itching and a burning sensation, while tretinoin may cause temporary changes in skin color. Additionally, tazarotene should not be used with benzoyl peroxide unless advised by a dermatologist, whereas tretinoin users should avoid products with drying agents like alcohol.
