Key takeaways
Sunosi (solriamfetol) and Wellbutrin (bupropion hydrochloride) are both medications that can affect norepinephrine and dopamine levels in the brain, but they are used for different reasons. Sunosi is a dopamine and norepinephrine reuptake inhibitor used to improve wakefulness in adults with narcolepsy or obstructive sleep apnea. In contrast, Wellbutrin is an atypical antidepressant used to treat depression and seasonal affective disorder (SAD). Sunosi is taken once daily in the morning, while Wellbutrin can be taken in various forms, including immediate-release, sustained-release, and extended-release, with dosing frequency ranging from once to three times a day. Sunosi is only available as a brand-name medication, whereas Wellbutrin is available as a lower-cost generic. Common side effects of Sunosi include headache, loss of appetite, and nausea, while Wellbutrin may cause headache, dry mouth, and trouble sleeping. Both medications can raise blood pressure and heart rate, and Wellbutrin increases the risk of seizures, especially in people with a history of seizures or eating disorders.
