Spravato vs. Auvelity for Depression: Important Differences and Potential Risks.

Spravato

(esketamine)

Auvelity

(dextromethorphan / bupropion)

Summary for Spravato

Prescription only

Spravato (esketamine) is used for adults with treatment-resistant depression (TRD). It also treats adults who have depression with suicidal thoughts or behavior. As an NMDA antagonist, it works in the brain to regulate mood. Spravato (esketamine) is a nasal spray that you must use at a treatment center. At first, you take it twice a week for 4 weeks. After that, people with treatment-resistant depression can take it once a week. Side effects include feeling sleepy and dissociated (disconnected from your thoughts or feelings). Side effects can be serious, so you must join the Spravato REMS program to get treatment.

Indications for Spravato

Treatment-resistant depression (TRD) in adults
Major depressive disorder in adults who have suicidal ideation or behavior

Pros and Cons for Spravato

Pros

Generally only need to take 1 or 2 times each week
Available through a REMS program that helps makes sure the medication is used safely
Can be used by itself for people with treatment-resistant depression who've already tried 2 oral antidepressants

Cons

Can't give the medication to yourself at home (must go to a treatment center to take)
Requires 2 to 3 sprays in each nostril for each dose
Serious risks of sleepiness; slowed breathing; and feeling disconnected with your thoughts, feelings, and sense of self

Common Side Effects for Spravato

Dissociation (disconnected from your thoughts, feelings, or sense of self, 41%)
Dizziness (29%)
Nausea (28%)
Sleepiness (23%)
Vertigo (feeling like the room is spinning, 23%)
Headache (20%)
Changes in taste (19%)
Numbness (18%)
Anxiety (13%)
Feeling sluggish (11%)
Higher blood pressure (10%)

Warnings for Spravato

Sleepiness, slowed breathing, and dissociation
Potential for misuse and dependence
Must enroll in the Spravato REMS program to get treated
Suicidal thoughts and behaviors in young adults
Higher blood pressure
Problems with your mental abilities (e.g., thinking, concentrating, remembering)
Bladder problems
Harm to an unborn baby

Summary for Auvelity

Prescription only

Auvelity (dextromethorphan / bupropion) is a newer antidepressant that's taken by mouth. It can work faster than some other antidepressants, but it's not a good choice for people with a history of seizures, eating disorders, severe kidney or liver problems, or alcohol abuse.

Indications for Auvelity

Depression

Pros and Cons for Auvelity

Pros

Works faster to treat depression symptoms compared to other antidepressants
Can be taken with or without food
Works well to improve depression symptoms in adults
Conveniently combines two medications into one tablet

Cons

Not recommended while pregnant or breastfeeding
Not studied in children
Brand only, so might be expensive
Can interact with many medications

Common Side Effects for Auvelity

Dizziness (16%)
Nausea (13%)
Headache (8%)
Diarrhea (7%)
Drowsiness (7%)
Dry mouth (6%)
Sexual problems (e.g., erectile dysfunction, low sex drive; 6%)
Sweating a lot (5%)

Warnings for Auvelity

Suicidal thoughts or behavior
Seizures
High blood pressure
Changes in thoughts, mood, or behavior
Serotonin syndrome
Harm to unborn babies

Prices with our coupons for Spravato vs. Auvelity

Spravato1 nasal spray / three 28mg nasal sprays of 84mg

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Auvelity60 tablets / 45mg/105mg

$1,199.00$1,504.78

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Spravato vs. Auvelity

Spravato

Auvelity

Summary for Spravato

Indications for Spravato

Pros and Cons for Spravato

Pros

Cons

Common Side Effects for Spravato

Warnings for Spravato

Summary for Auvelity

Indications for Auvelity

Pros and Cons for Auvelity

Pros

Cons

Common Side Effects for Auvelity

Warnings for Auvelity

Prices with our coupons for Spravato vs. Auvelity

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Spravato

Auvelity

Summary for Spravato

Indications for Spravato

Pros and Cons for Spravato

Pros

Cons

Common Side Effects for Spravato

Warnings for Spravato

Summary for Auvelity

Indications for Auvelity

Pros and Cons for Auvelity

Pros

Cons

Common Side Effects for Auvelity

Warnings for Auvelity