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Savaysa vs. Eliquis

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Savaysa (edoxaban) and Eliquis (apixaban) are both blood thinners used to prevent blood clots and strokes, but they have some differences. Savaysa is taken once daily, while Eliquis is taken twice daily. Savaysa does not have a generic version available, making it potentially more expensive, whereas Eliquis has a generic version approved but may not available until 2026. Savaysa isn’t recommended for people whose kidneys work too fast or too slow. Eliquis might be a better option for those with certain kidney problems. Eliquis can be used to prevent blood clots after hip or knee replacement surgery, but Savaysa isn’t used for this. Both medications can cause bleeding, but Eliquis has an antidote, while Savaysa doesn’t.

Savaysa

(edoxaban)

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Eliquis

(apixaban)

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Summary for Savaysa

Prescription only

Savaysa, the brand name for edoxaban, is an anticoagulant (blood thinner). It’s used to help prevent blood clots and strokes in certain people with atrial fibrillation. This medication can also treat blood clots. The dose is typically one 60 mg tablet by mouth once daily, but it might be lower if you have kidney problems. Since it’s a blood thinner medication, Savaysa (edoxaban) can raise your chance of bleeding as a side effect. As of early 2025, there's no FDA-approved generic version available yet.

Indications for Savaysa

Pros and Cons for Savaysa

Pros

  • Oral medication that's only taken once a day
  • Can take with or without food and doesn't interact with any specific foods
  • Doesn't require frequent blood tests to check how well it’s working and how safe it is

Cons

Common Side Effects for Savaysa

  • Any type of bleeding

Warnings for Savaysa

  • Less effective for people with atrial fibrillation whose kidneys work too well
  • Higher risk of blood clots or stroke when you stop the medication too soon
  • Bleeding risk
  • Risk of bleeding around the spinal cord after spinal procedures
  • Higher risk of clotting in people with triple-positive antiphospholipid syndrome

Summary for Eliquis

Prescription only

Eliquis (apixaban) is an anticoagulant (blood thinner) used to prevent and treat blood clots. It can lower the risk of serious conditions like stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). The medication comes as a tablet or liquid and is taken by mouth twice a day. Common side effects include bleeding and bruising. Although generic versions have been approved by the FDA, they might not be available until 2026.

Indications for Eliquis

Adults:

Children:

  • Treat blood clots and lower the risk of new clots in children from birth and older

Pros and Cons for Eliquis

Pros

  • No regular blood monitoring required
  • Can be taken with or without food
  • Approved for both children and adults

Cons

  • Need to take it twice a day
  • Most common side effect is bleeding
  • Not easily reversible in life-threatening bleeds

Common Side Effects for Eliquis

Adults:

  • Any bleeding (up to 15%)

Children:

  • Any bleeding (up to 36%)
  • Headache (16%)
  • Vomiting (14%)

Warnings for Eliquis

  • Higher risk of blood clots if stopped too early
  • Paralysis in the spine
  • Bleeding
  • Not recommended in people with prosthetic heart valves
  • Not recommended in people with antiphospholipid syndrome

Prices with our coupons for Savaysa vs. Eliquis

Price Card Drug Icon
Savaysa30 tablets / 60mg
$446.63$548.12
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Price Card Drug Icon
Eliquis60 tablets / 5mg
$346.17$784.28
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