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Ryaltris vs. Flonase

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ryaltris (olopatadine/mometasone) and Flonase (fluticasone) are both nasal sprays used to treat allergy symptoms like runny nose and sneezing. They both help with nasal symptoms, but they have some differences. Ryaltris is a combination of an antihistamine (olopatadine) and a corticosteroid (mometasone), while Flonase is a corticosteroid (fluticasone) only. Ryaltris is available by prescription only while Flonase can be bought over-the-counter. Ryaltris is typically used twice daily, while Flonase can be used once or twice daily. Ryaltris is approved for people ages 12 and older, whereas Flonase can be used in children as young as 2 years old, depending on the formulation. Ryaltris doesn't commonly cause side effects, but can cause a bad taste in the mouth and nosebleeds, while Flonase can cause headaches and sore throats. Ryaltris may interact with some medications, like clarithromycin, ritonavir, and itraconazole. Make sure your prescriber and pharmacist have a complete list of your medications.

Ryaltris

(olopatadine / mometasone)

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fluticasone nasal spray

 

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Summary for Ryaltris

Prescription only

Ryaltris is a combination of two medications: olopatadine (an antihistamine) and mometasone (a corticosteroid). It's a nasal spray used to treat eye and nasal symptoms of seasonal allergies (e.g., runny nose, stuffy nose, sneezing, itchy eyes) in people ages 12 and older. The dosage is 2 sprays in each nostril twice per day. Ryaltris (olopatadine / mometasone) doesn't have a generic version since it's only available as a brand-name medication. Side effects aren't common, but include a bad taste in the mouth and nosebleeds.

Indications for Ryaltris

  • Eye and nasal symptoms of seasonal allergies (e.g., runny nose, stuffy nose, sneezing, itchy eyes)

Pros and Cons for Ryaltris

Pros

  • Combines two first-choice medications into a single spray
  • Starts to work within 15 minutes
  • Less side effects than antihistamines and steroids taken by mouth

Cons

  • Can cause nosebleeds and nasal irritation
  • Need to use twice per day
  • Available by prescription only

Common Side Effects for Ryaltris

Warnings for Ryaltris

  • Nasal problems
  • Drowsiness
  • Eye and vision problems
  • Allergic reactions
  • Risk of infection
  • Altered stress hormone levels
  • Slowed growth in children

Summary for Flonase

Prescription or over-the-counter

Fluticasone nasal spray is used to treat allergy symptoms, like runny nose and sneezing. Fluticasone nasal spray comes in brand and generic forms, and is available by a prescription or over-the-counter (OTC). Fluticasone nasal spray must be used daily in order for you to experience the maximum benefits. But if you're using OTC versions of this medication, don't use it for more than 6 months at a time (or 2 months at a time, for children) without first speaking to your provider.

Indications for Flonase

Nasal symptoms from allergies, such as:

  • Congestion
  • Runny nose
  • Sneezing
  • Itchy nose
  • Itchy, watery eyes

Pros and Cons for Flonase

Pros

  • Only has to be used once a day and can last up to 24 hours
  • Available OTC
  • Some formulations have generic versions
  • Can be used safely in children as young as 4 years old
  • Flonase Sensimist is a gentler version that can be used in children as young as 2 years old

Cons

  • Not a good option if you have an injured nose or had recent nasal surgery
  • Can raise the risk of bleeding and fungal infections in the nose
  • Can slow down growth rate in children if used for longer than 2 months per year
  • Can raise the risk for certain eye problems

Common Side Effects for Flonase

  • Headache (7-16%)
  • Sore throat (6-8%)
  • Nosebleeds (6-7%)
  • Asthma symptoms (3-7%)

Warnings for Flonase

  • Nasal problems
  • Slowed growth rate in children
  • Eye problems
  • Higher risk of infections
  • Stress hormone problems (adrenal gland problems)
  • Serious allergic reactions

Prices with our coupons for Ryaltris vs. Flonase

Price Card Drug Icon
Ryaltris1 nasal spray / 240 metered sprays of 665mcg/25mcg/spray
$45.52$305.78
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Fluticasone Propionate1 nasal spray / 16g of 50mcg
$14.67$47.00
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