Key takeaways
Ramelteon (Rozerem) and trazodone are both used to help with sleep, but they work in different ways and have different primary uses. Ramelteon is a melatonin receptor agonist that mimics the natural hormone melatonin to help you fall asleep. It's specifically approved for treating insomnia and is not habit-forming. Trazodone, on the other hand, is an atypical antidepressant primarily approved for treating major depressive disorder (MDD) but is often used off-label for insomnia. Unlike ramelteon, trazodone affects serotonin levels in the brain and can cause more side effects like sleepiness, dry mouth, and dizziness. Ramelteon is taken once before bedtime, while trazodone can be taken multiple times a day for depression or once at bedtime for sleep. Additionally, trazodone can cause withdrawal symptoms if stopped suddenly, whereas ramelteon does not. Both medications are available in generic forms.
