Key takeaways
Risperidone (Risperdal) and quetiapine (Seroquel) are both atypical antipsychotics used to treat schizophrenia and bipolar disorder. Risperidone is also used for irritability associated with autism, while quetiapine can be used as an add-on treatment for depression in its extended-release form. Risperidone is typically taken once or twice daily, whereas quetiapine's immediate-release form needs to be taken two to three times a day, and the extended-release form is taken once daily. Risperidone is available as a pill, dissolvable tablet, and liquid, while quetiapine comes in immediate-release and extended-release tablets. Both medications can cause weight gain and raise blood sugar levels, but quetiapine is more likely to raise blood cholesterol levels. Risperidone can cause movement problems and sleepiness, while quetiapine can cause sleepiness, dry mouth, and constipation. Both medications should not be used in older adults with dementia-related psychosis due to a higher risk of death.
