Key takeaways
Propranolol (Inderal LA, Inderal XL, Innopran XL) and ergotamine/caffeine (Cafergot, Migergot) are both prescription medications, but they serve different purposes and belong to different drug classes. Propranolol is a non-selective beta blocker used to treat conditions like high blood pressure, chronic chest pain, and migraines, and it can also be used off-label for performance anxiety. It is available in both immediate-release and extended-release forms, which are taken by mouth. Common side effects include dizziness, tiredness, and weakness. On the other hand, ergotamine/caffeine is an ergot derivative combined with caffeine, used specifically to treat migraines and cluster headaches. It is available as a tablet or a rectal suppository. This medication is taken as soon as you feel a headache coming on, but it has a limit on how many doses you can take per week due to the risk of serious side effects like vomiting and numbness. Unlike propranolol, ergotamine/caffeine is not safe for use during pregnancy and has more specific contraindications, such as heart disease and high blood pressure. While both medications can help with migraines, propranolol is used more for prevention, whereas ergotamine/caffeine is used for acute treatment.
