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Prolia vs. Xgeva

Prolia (denosumab) is an injection that's used to treat osteoporosis in adults at high risk of fracture. It's also for those at high risk of fractures from certain cancer medications. It works as a monoclonal antibody called a RANKL inhibitor to strengthen your bones. Prolia (denosumab) is a convenient option because you only need an injection every 6 months. It's injected under the skin by a healthcare professional at a medical office. Side effects include back and muscle pain. It also has a risk of causing dangerously low calcium levels.

• Osteoporosis in women who've gone through menopause and at high risk of fracture
• Osteoporosis in men at high risk of fracture
• Osteoporosis caused by steroid medications in people at high risk of fracture
• Bone loss in men at high risk of fracture taking certain medications for prostate cancer
• Bone loss in women at high risk of fracture taking certain breast cancer medications

• Back pain (35%)
• Pain in the arm or leg (12%)
• Muscle, bone, or joint pain (up to 8%)
• High cholesterol levels (7%)
• Pain or discomfort while urinating and other symptoms of a bladder infection (6%)
• Sensation that the room is spinning (5%)
• Swelling in the hands or feet (5%)
• Upper respiratory tract infection (5%)

• Dangerously low calcium levels
• Risk of fractures in the thigh bone
• Risk of spine fractures after stopping Prolia (denosumab)
• Risk of serious infections
• Risk of problems in the jawbone
• Serious allergic reactions and skin reactions
• Severe bone, muscle, or joint pain
• Don't take with Xgeva (denosumab)

Xgeva (denosumab) is a RANKL inhibitor that helps prevent the breakdown of bones. It's used to prevent bone problems in adults with certain types of cancer, like breast cancer and prostate cancer, that have spread to the bones. It's also used to lower calcium levels in people who have cancer (hypercalcemia of malignancy). Xgeva (denosumab) is given as an injection under the skin, typically once per month by a healthcare professional (HCP). Common side effects of this medication include fatigue and nausea.

• Prevention of broken bones in adults with multiple myeloma (MM) or cancer that has spread to the bones
• Giant cell tumor of bone in adults and children ages 12 years and older who can't receive surgery
• High calcium levels caused by cancer (hypercalcemia of malignancy) in adults

• Fatigue (45%)
• Low blood phosphorus levels (32%)
• Nausea (31%)
• Shortness of breath (21%)
• Diarrhea (20%)
• Low blood calcium levels (18%)
• Cough (15%)
• Headache (13%)

• Low calcium levels
• High calcium levels after stopping treatment
• Problems in the jaw bone (osteonecrosis)
• Thigh bone fractures
• Spine fractures after stopping treatment
• Harm to your unborn baby
• Serious allergic reactions