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Prempro vs. Minivelle

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe vaginal symptoms due to menopause, like vaginal dryness and irritation
• Prevention of bone loss (osteoporosis) after menopause

• Breast pain (up to 36%)
• Headaches (up to 19%)
• Stomach pain (up to 17%)
• Menstrual cramps (up to 13%)
• Gas (up to 8%)
• Nausea (up to 8%)
• Depression (up to 8%)
• More vaginal discharge than usual (up to 8%)

• Risk of blood clot
• Breast cancer
• Uterine (endometrial) cancer
• Dementia
• Gallbladder and liver problems
• Changes in calcium levels in the blood
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Severe allergic reaction
• Worsening of other medical conditions

Minivelle (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, caused by menopause. It can also prevent bone loss (osteoporosis) after menopause. It's a type of hormone replacement therapy. The usual dose is one patch applied to the lower stomach or buttocks twice a week, or every 3 to 4 days. Potential side effects include headache, breast tenderness, and back pain.

• Hot flashes, night sweats, and flushes caused by menopause
• Prevent osteoporosis that happens after menopause

• Headache (up to 50%)
• Common cold symptoms (up to 20%)
• Breast tenderness (up to 17%)
• Sinus swelling (up to 13%)
• Bleeding in-between periods (up to 11%)
• Depression (up to 11%)
• Back pain (up to 11%)
• Sinus headache (up to 10%)
• Indigestion (up to 9%)
• Weight gain (up to 9%)
• Joint pain (up to 9%)

• Blood clots and related complications (e.g., heart attack, stroke)
• Uterine (endometrial) cancer
• Breast cancer
• Ovarian cancer
• Dementia
• Gallbladder and liver problems
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Severe allergic reactions
• Worsening of other health conditions